Journal ArticleDOI
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action.
Franz X. Vollenweider,Margreet F. I. Vollenweider-Scherpenhuyzen,Andreas Bäbler,Helen Vogel,Daniel Hell +4 more
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TLDR
In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotics risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol.Abstract:
Psilocybin, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. These data are consistent with animal studies and provide the first evidence in humans that psilocybin-induced psychosis is due to serotonin-2A receptor activation, independently of dopamine stimulation. Thus, serotonin-2A overactivity may be involved in the pathophysiology of schizophrenia and serotonin-2A antagonism may contribute to therapeutic effects of antipsychotics. Language: enread more
Citations
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Hallucinogenic drugs attenuate the subjective response to alcohol in humans.
TL;DR: It is proposed that LSD's effect on alcohol intoxication may involve interactions with various serotonergic and/or dopaminergic receptor systems.
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A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers
J. Reckweg,Natasha L. Mason,Cees J Van Leeuwen,Stefan W. Toennes,Theis H. Terwey,Johannes G. Ramaekers +5 more
TL;DR: In this article, the impact of individualized dose escalation of 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) on cognitive functioning, mood, and well-being was investigated in patients with depression.
Journal ArticleDOI
Serotonergic Psychedelics in Neural Plasticity
TL;DR: In this paper, the role of serotonergic psychedelics in neural plasticity and its implication for their therapeutic potentials is discussed. But, the authors do not discuss the effect of these drugs on human brain.
Journal ArticleDOI
Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain.
Tatsuya Ishii,Tatsuya Ishii,Yasuyuki Kimura,Masanori Ichise,Keisuke Takahata,Soichiro Kitamura,Sho Moriguchi,Manabu Kubota,Ming-Rong Zhang,Makiko Yamada,Makoto Higuchi,Yoshinori Okubo,Tetsuya Suhara +12 more
TL;DR: In this article, the authors investigated regional relationships between 5-HT2A and D2 receptors using positron emission tomography (PET) and bicluster analysis of the correlation matrix of individual variation in the two receptor densities to identify groups of distinctive regional correlations between the two receptors.
References
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Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens
TL;DR: Results indicate that an important component of the mechanism of action of LSD and the phenylisopropylamine hallucinogens is through stimulation of brain 5-HT2 receptors, and supports previous suggestions to this effect.
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Alterations in the cortical serotonergic system in schizophrenia: A postmortem study
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Journal ArticleDOI
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Daniel Hoyer,Philippe Schoeffter +1 more
TL;DR: Three main families of 5-HT receptors, of which subtypes have been described, are now accepted, and heterogeneity is further substantiated by the cloning of the cDNA's of three different 5- HT receptors.