Journal ArticleDOI
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action.
Franz X. Vollenweider,Margreet F. I. Vollenweider-Scherpenhuyzen,Andreas Bäbler,Helen Vogel,Daniel Hell +4 more
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TLDR
In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotics risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol.Abstract:
Psilocybin, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. These data are consistent with animal studies and provide the first evidence in humans that psilocybin-induced psychosis is due to serotonin-2A receptor activation, independently of dopamine stimulation. Thus, serotonin-2A overactivity may be involved in the pathophysiology of schizophrenia and serotonin-2A antagonism may contribute to therapeutic effects of antipsychotics. Language: enread more
Citations
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Journal ArticleDOI
Psychedelic Targeting of Metabotropic Glutamate Receptor 2 and Its Implications for the Treatment of Alcoholism
TL;DR: In this article , the authors synthesize well-established knowledge from addiction research about pathophysiological mechanisms related to the metabotropic glutamate receptor 2 (mGlu2), with findings and theories on how mGlu 2 connects to the major signaling pathways induced by psychedelics via serotonin 2A receptors (2AR).
Journal ArticleDOI
Utility of preclinical models in the study of psilocybin – A comprehensive review
TL;DR: A systematic search of the literature identified 57 articles involving the study of psilocybin in preclinical rodent models, with pharmacology, toxicity, effects on disease models, and molecular mechanisms accounting for the majority as mentioned in this paper .
Book ChapterDOI
Psilocybin as an Inducer of Ego Death and Similar Experiences of Religious Provenance
TL;DR: In this article, an overview of the impact of hallucinogenic psilocybin on religious-type emotionality related to ego disintegration is provided. And the connection between the drug-induced experiences similar to schizophrenia-like psychosis and religious type emotionality is emphasized in this chapter.
Posted ContentDOI
The unique neural signature of your trip: Functional connectome fingerprints of subjective psilocybin experience
Hanna M. Tolle,Juan Carlos Farah,P. Mallaroni,Natasha L. Mason,Johannes G. Ramaekers,Enrico Amico +5 more
TL;DR: In this article , the authors harness brain fingerprinting tools to extract functional connectomes (FCs) features that predict subjective drug experience induced by the psychedelic psilocybin and show that FCs become more idiosyncratic due to greater inter-subject dissimilarity.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
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Daniel Hoyer,Philippe Schoeffter +1 more
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