Journal ArticleDOI
Quantifying rapid bacterial evolution and transmission within the mouse intestine.
Kimberly S. Vasquez,Lisa Willis,Nate Cira,Katharine M. Ng,Miguel F. Pedro,Andrés Aranda-Díaz,Manohary Rajendram,Feiqiao Brian Yu,Steven K. Higginbottom,Norma Neff,Gavin Sherlock,Karina B. Xavier,Stephen R. Quake,Justin L. Sonnenburg,Benjamin H. Good,Benjamin H. Good,Kerwyn Casey Huang +16 more
TLDR
In this article, the authors introduced hundreds of barcoded Escherichia coli strains into germ-free mice and quantified strain-level dynamics and metagenomic changes, highlighting the interplay between environmental transmission and rapid, deterministic selection during evolution of the intestinal microbiota.About:
This article is published in Cell Host & Microbe.The article was published on 2021-09-08. It has received 14 citations till now.read more
Citations
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Journal ArticleDOI
Quantifying the local adaptive landscape of a nascent bacterial community
TL;DR: In this paper , the fitness effects of all possible mutations available to an organism largely shape the dynamics of evolutionary adaptation, and whether and how this adaptive landscape changes over evolutionary times, especially upon ecological diversification and changes in community composition, remains poorly understood.
Journal ArticleDOI
Emergent evolutionary forces in spatial models of luminal growth and their application to the human gut microbiota
Olivia M Ghosh,Benjamin M. Good +1 more
TL;DR: A population genetic framework is introduced to predict how stochastic evolutionary forces emerge from simple models of microbial growth in spatially extended environments like the intestinal lumen, and shows how fluid flow and longitudinal variation in growth rate combine to shape the frequencies of genetic variants in simulated fecal samples.
Posted ContentDOI
Quantifying the Local Adaptive Landscape of a Nascent Bacterial Community
TL;DR: In this article , the fitness effects of all possible mutations available to an organism largely shape the dynamics of evolutionary adaptation, and the adaptive potential of strains that are part of multi-strain communities remains largely unclear.
Posted ContentDOI
BlpC-mediated selfish program leads to rapid loss of Streptococcus pneumoniae clonal diversity during infection
Surya D. Aggarwal,John A. Lees,Nathan T. Jacobs,Gavyn Chern Wei Bee,Annie Abruzzo,Jeffrey N. Weiser +5 more
TL;DR: It is shown that genetic variation in the blp locus is associated with transmissibility in the human population and posit this is due to its importance in clonal selection and its role as a selfish element.
Posted ContentDOI
Dynamic genetic adaptation of Bacteroides thetaiotaomicron murine gut colonization
Manjing Zhang,Megan Kennedy,Orlando DeLeon,J. Bissell,Florian Trigodet,Karen Lolans,Sara Temelkova,Katherine T. Carroll,Aretha Fiebig,Adam M. Deutschbauer,Ashley M. Sidebottom,Christopher S. Henry,Phoebe A. Rice,Joy Bergelson,Eugene B. Chang +14 more
TL;DR: Light is shed on host colonization by Bacteroides thetaiotaomicron, an organism that is prevalent and dominant across healthy human microbiomes, and not only identifies key pathways involved in colonization, but determines the timing of when these pathways are most vital to colonization success.
References
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Journal ArticleDOI
Yersinia pestis--etiologic agent of plague.
R D Perry,J D Fetherston +1 more
TL;DR: The present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague is updated.
Journal ArticleDOI
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease.
TL;DR: Understanding the interaction of the microbiota with pathogens and the immune system will provide critical insight into the pathogenesis of disease and the development of strategies to prevent and treat inflammatory disease.
Journal ArticleDOI
A Tn7-based broad-range bacterial cloning and expression system
Kyoung-Hee Choi,Jared B. Gaynor,Kimberly G. White,Carolina M. López,Catharine M. Bosio,RoxAnn R. Karkhoff-Schweizer,Herbert P. Schweizer +6 more
TL;DR: The Tn7 system allows engineering of diverse genetic traits into bacteria, as demonstrated by complementing a biofilm-growth defect of P. aeruginosa, establishing expression systems in P. putida and Yersinia pestis, and 'GFP-tagging' Y. pestis.
Journal ArticleDOI
A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
Dylan Dodd,Matthew H. Spitzer,Matthew H. Spitzer,Will Van Treuren,Bryan D. Merrill,Andrew J. Hryckowian,Steven K. Higginbottom,Anthony Le,Tina M. Cowan,Garry P. Nolan,Michael A. Fischbach,Justin L. Sonnenburg +11 more
TL;DR: This work uses a combination of genetics and metabolic profiling to characterize a pathway from the gut symbiont Clostridium sporogenes that generates aromatic amino acid metabolites, and reveals that this pathway produces twelve compounds, nine of which are known to accumulate in host serum.