Journal ArticleDOI
Quantitative cancer inhibitory of hydroxytyrosol in olive oil compounds: an overview of observational and experimental studies
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TLDR
Hydroxytyrosol, one of the main phenolic compounds in olives, virgin oil and waste water obtained during the production of olive oil, was shown to prevent atherosclerosis through the inhibition of LDL oxidation and inhibit different kinds of cancer.Abstract:
Hydroxytyrosol (HTyr), an important phenol present in olives, stands out as a compound of high value due to its excellent antioxidant, antimicrobial and anticarcinogenic activities. Hydroxytyrosol (HTyr, 4-(2-(hydroxyethyl)-1,2-benzendiol)) is one of the main phenolic compounds in olives, virgin oil and waste water obtained during the production of olive oil. HTyr has been confirmed as the antioxidant with the highest free radical scavenging capacity, and is more active than antioxidant vitamins (C and E) as well as the synthetic antioxidants. Studies (human, animal, in vivo and in vitro) have shown many beneficial attributes of this ortho-diphenol compound, e.g. anti-inflammatory activity and inhibition of platelet aggregation. Similar to other polyphenols, HTyr was shown to prevent atherosclerosis through the inhibition of LDL oxidation. Furthermore, polyphenols extracted from the virgin olive oil containing mainly HTyr were also shown to inhibit different kinds of cancer, e.g. proliferation of ...read more
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Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells
D Loru,Alessandra Incani,Monica Deiana,Giulia Corona,Angela Atzeri,Maria Paola Melis,Antonella Rosa,Ma Dessì +7 more
TL;DR: Hydroxytyrosol exerted a significant antioxidant action, inhibiting the production of MDA, fatty acids hydroperoxides and 7-ketocholesterol, major oxidation products of unsaturated fatty acids and cholesterol, and thus protecting the cells from H2O2-induced damage.
References
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Journal ArticleDOI
Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial.
Katherine Esposito,Raffaele Marfella,Miryam Ciotola,Carmen Di Palo,Francesco Giugliano,Giovanni Giugliano,Massimo D’Armiento,Francesco D'Andrea,Dario Giugliano +8 more
TL;DR: After 2 years of follow-up, patients following the Mediterranean-style diet consumed more foods rich in monounsaturated fat, polyunsaturatedfat, and fiber and had a lower ratio of omega-6 to omega-3 fatty acids.
Journal ArticleDOI
Phenolic Acids in Foods: An Overview of Analytical Methodology
TL;DR: The masses and MS fragmentation patterns of phenolic acids are discussed and tabulated as are the UV absorption maxima.
Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic Syndrome
Raffaele Marfella,Miryam Ciotola,Carmen Di Palo,Francesco Giugliano,Giovanni Giugliano,Dario Giugliano +5 more
TL;DR: A randomized, single-blind trial conducted from June 2001 to January 2004 at a university hospital in Italy among 180 patients with the metabolic syndrome, as defined by the Adult Treatment Panel III, was conducted to assess the effect of a Mediterranean-style diet on endothelial function and vascular inflammatory markers in patients with metabolic syndrome.
Journal ArticleDOI
Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes.
TL;DR: The latest studies strongly suggest that dietary polyphenols can stimulate antioxidant transcription and detoxification defense systems through AREs present in the promoter regions of many of the genes inducible by oxidative and chemical stress.
Journal ArticleDOI
Phytochemistry: ibuprofen-like activity in extra-virgin olive oil.
Gary K. Beauchamp,Russell Keast,Russell Keast,Diane W. Morel,Jianming Lin,Jana Pika,Qiang Han,Chi-Ho Lee,Chi-Ho Lee,Amos B. Smith,Amos B. Smith,Paul A. S. Breslin +11 more
TL;DR: It is shown that newly pressed extra-virgin olive oil contains oleocanthal, a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen, which is an indicator of a shared pharmacological activity.