Journal ArticleDOI
Radiobiological parameters of liver and lung metastases derived from tumor control data of 3719 metastases.
TLDR
In this paper, the radiobiological parameters for liver and lung metastases treated with stereotactic body radiation therapy (SBRT) are poorly defined and a project aimed at estimating these parameters from published tumor control probability (TCP) data, and separately for metastases with colorectal cancer (CRC) and non-CRC histology.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-01. It has received 28 citations till now.read more
Citations
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Journal ArticleDOI
The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases
N. Andratschke,H. Alheid,Michael Allgäuer,Gerhild Becker,Oliver Blanck,Judit Boda-Heggemann,Thomas B. Brunner,Marciana-Nona Duma,Sabine Gerum,Matthias Guckenberger,Guido Hildebrandt,Rainer J. Klement,V. Lewitzki,C. Ostheimer,Alexandros Papachristofilou,Cordula Petersen,Thomas Schneider,Robert Semrau,Stefan Wachter,Daniel Habermehl +19 more
TL;DR: After an initial learning curve with regards to total cumulative doses, consistently high biologically effective doses have been employed translating into high local tumor control at 1 and 2 years and overall survival is mainly influenced by histology and metastatic tumor burden.
Journal ArticleDOI
Stereotactic body radiotherapy for colorectal cancer liver metastases: A systematic review.
Fausto Petrelli,Tiziana Comito,Sandro Barni,Gianfranco Pancera,Marta Scorsetti,Antonio Ghidini,Sbrt for Crc liver metastases +6 more
TL;DR: SBRT for liver oligometastases is an effective option for patients with advanced CRC, with encouraging local control and survival, with a moderate/poor linear relationship between the SBRT (BED10) dose and LC.
Journal ArticleDOI
Stereotactic Body Radiotherapy for Colorectal Liver Metastases: A Pooled Analysis
Daniel T. Chang,A. Swaminath,Margaret M. Kozak,J. Weintraub,Albert C. Koong,John Kim,Laura A. Dawson,Brian D. Kavanagh,Tracey E. Schefter +8 more
Journal ArticleDOI
Phase II trial on SBRT for unresectable liver metastases: long-term outcome and prognostic factors of survival after 5 years of follow-up
Marta Scorsetti,Tiziana Comito,Elena Clerici,Ciro Franzese,Angelo Tozzi,Cristina Iftode,Lucia Di Brina,Pierina Navarria,Pietro Mancosu,Giacomo Reggiori,Antonella Fogliata,Stefano Tomatis,Guido Torzilli,Luca Cozzi +13 more
TL;DR: Long-term results of this Phase II study suggest the efficacy and safety of SBRT for un-resectable liver metastases after 5-year of follow up and selection of cases with positive prognostic factors may improve long-term survival of these oligo-metastastic patients.
Journal ArticleDOI
The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases
Rainer J. Klement,N. Abbasi-Senger,Sonja Adebahr,H. Alheid,M. Allgaeuer,Gerhild Becker,Oliver Blanck,Judit Boda-Heggemann,Thomas Brunner,Marciana Nona Duma,Michael J. Eble,Iris Ernst,Sabine Gerum,Daniel Habermehl,Daniel Habermehl,Peter Hass,Christoph Henkenberens,Guido Hildebrandt,Detlef Imhoff,H. Kahl,N. D. Klass,Robert Krempien,V. Lewitzki,Fabian Lohaus,C. Ostheimer,Alexandros Papachristofilou,C. Petersen,Juliane Rieber,Thomas Schneider,E. Schrade,Robert Semrau,Stefan Wachter,Andrea Wittig,Matthias Guckenberger,Nicolaus Andratschke +34 more
TL;DR: In this article, the effect of local control (LC) on overall survival (OS) in patients treated with stereotactic body radiotherapy (SBRT) for liver or lung metastases from colorectal cancer was investigated.
References
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Journal ArticleDOI
Bayesian measures of model complexity and fit
TL;DR: In this paper, the authors consider the problem of comparing complex hierarchical models in which the number of parameters is not clearly defined and derive a measure pD for the effective number in a model as the difference between the posterior mean of the deviances and the deviance at the posterior means of the parameters of interest, which is related to other information criteria and has an approximate decision theoretic justification.
Journal ArticleDOI
Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves
TL;DR: An algorithm that maps from digitised curves back to KM data by finding numerical solutions to the inverted KM equations is developed, which is a reliable tool for meta-analysis and cost-effectiveness analyses of RCTs reporting time-to-event data.
Journal ArticleDOI
Multi-Institutional Phase I/II Trial of Stereotactic Body Radiation Therapy for Lung Metastases
Kyle E. Rusthoven,Brian D. Kavanagh,Stuart H. Burri,Changhu Chen,Higinia R. Cardenes,Mark Chidel,Thomas J. Pugh,Madeleine A. Kane,Laurie E. Gaspar,Tracey E. Schefter +9 more
TL;DR: This multi-institutional phase I/II trial demonstrates that high-dose SBRT is safe and effective for the treatment of patients with one to three lung metastases.
Journal ArticleDOI
Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy.
TL;DR: The aim of this study was to offer an alternative method of analyzing the effect of SBRT by constructing a universal survival curve (USC) that provides superior approximation of the experimentally measured survival curves in the ablative, high-dose range without losing the strengths of the LQ model around the shoulder.
Journal ArticleDOI
Stereotactic single-dose radiation therapy of liver tumors: results of a phase I/II trial.
Klaus Herfarth,Jürgen Debus,Frank Lohr,Malte L. Bahner,Bernhard Rhein,Peter Fritz,Angelika Höss,Wolfgang Schlegel,Michael Wannenmacher +8 more
TL;DR: Stereotactic single-dose radiation therapy is a feasible method for the treatment of singular inoperable liver metastases with the potential of a high local tumor control rate and low morbidity.
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