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Journal ArticleDOI

Randomised controlled trial of faecal-occult-blood screening for colorectal cancer

TLDR
Evidence from this study and other trials suggest that consideration should be given to a national programme of FOB screening to reduce CRC mortality in the general population.
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This article is published in The Lancet.The article was published on 1989-05-01. It has received 2778 citations till now. The article focuses on the topics: Mass screening & Population.

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Citations
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Colorectal cancer screening and surveillance: clinical guidelines and rationale-update based on new evidence

TL;DR: These guidelines differ from those published in 1997 in several ways: the screening interval for double contrast barium enema has been shortened to 5 years, and colonoscopy is the preferred test for the diagnostic investigation of patients with findings on screening and for screening patients with a family history of hereditary nonpolyposis colorectal cancer.
Journal ArticleDOI

Colorectal cancer screening: Clinical guidelines and rationale

TL;DR: This guideline report presents the panel’s recommendations with respect to screening and surveillance in people at average risk for CRC and those at increased risk because of a family history of CRC or genetic syndromes or a personal history of adenomatous polyps, inflammatory bowel disease, or curative-intent resection of CRC.
Journal ArticleDOI

Use of Colonoscopy to Screen Asymptomatic Adults for Colorectal Cancer

TL;DR: Colonoscopic screening can detect advanced colonic neoplasms in asymptomatic adults with or without distal neoplasia, and many of these neoplasm would not be detected with sigmoidoscopy.
References
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Journal ArticleDOI

Reducing Mortality from Colorectal Cancer by Screening for Fecal Occult Blood

TL;DR: Cutting mortality in the annually screened group was accompanied by improved survival in those with colorectal cancer and a shift to detection at an earlier stage of cancer.
Journal ArticleDOI

Randomised study of screening for colorectal cancer with faecal-occult-blood test

TL;DR: The findings indicate that biennial screening by FOB tests can reduce CRC mortality, and the effect of the removal of more precursor adenomas in the screening-group participants than in controls on CRC incidence.
Journal ArticleDOI

The classification of cancer of the rectum

TL;DR: The scope and limitations of histological grading by Broders' method are discussed and the conclusions reached that grading of a tumour is also of value for prognosis, though not when applied to fragments removed for diagnosis.
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