Journal ArticleDOI
Randomized Phase III Study of Surgery Alone or Surgery Plus Preoperative Cisplatin and Gemcitabine in Stages IB to IIIA Non–Small-Cell Lung Cancer
Giorgio V. Scagliotti,Ugo Pastorino,Johan Vansteenkiste,Lorenzo Spaggiari,Francesco Facciolo,Tadeusz M. Orlowski,Luigi Maiorino,Martin Hetzel,Monika I. Leschinger,Carla Visseren-Grul,Valter Torri +10 more
TLDR
Although the study was terminated early, preoperative gemcitabine plus cisplatin followed by radical surgery improved survival in patients with clinical stage IIB/IIIA NSCLC.Abstract:
Purpose This study aimed to determine whether three preoperative cycles of gemcitabine plus cisplatin followed by radical surgery provides a reduction in the risk of progression compared with surgery alone in patients with stages IB to IIIA non–small-cell lung cancer (NSCLC). Patients and Methods Patients with chemotherapy-naive NSCLC (stages IB, II, or IIIA) were randomly assigned to receive either three cycles of gemcitabine 1,250 mg/m 2 days 1 and 8 every 3 weeks plus cisplatin 75 mg/m 2 day 1 every 3 weeks followed by surgery, or surgery alone. Randomization was stratified by center and disease stage (IB/IIA v IIB/IIIA). The primary end point was progression-free survival (PFS). Results The study was prematurely closed after the random assignment of 270 patients: 129 to chemotherapy plus surgery and 141 to surgery alone. Median age was 61.8 years and 83.3% were male. Slightly more patients in the surgery alone arm had disease stage IB/IIA (55.3% v 48.8%). The chemotherapy response rate was 35.4%. The hazard ratios for PFS and overall survival were 0.70 (95% CI, 0.50 to 0.97; P .003) and 0.63 (95% CI, 0.43 to 0.92; P .02), respectively, both in favor of chemotherapy plus surgery. A statistically significant impact of preoperative chemotherapy on outcomes was observed in the stage IIB/IIIA subgroup (3-year PFS rate: 36.1% v 55.4%; P .002). The most common grade 3 or 4 chemotherapy-related adverse events were neutropenia and thrombocytopenia. No treatment-by-histology interaction effect was apparent. Conclusion Although the study was terminated early, preoperative gemcitabine plus cisplatin followed by radical surgery improved survival in patients with clinical stage IIB/IIIA NSCLC.read more
Citations
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NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines
TL;DR: Lymphedema is a common complication after treatment for breast cancer and factors associated with increased risk of lymphedEMA include extent of axillary surgery, axillary radiation, infection, and patient obesity.
Journal ArticleDOI
Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Johan Vansteenkiste,Dirk De Ruysscher,Wilfried Eberhardt,Eric Lim,Suresh Senan,Enriqueta Felip,Solange Peters +6 more
TL;DR: The Clatterbridge Cancer Centre and Liverpool Heart and Chest Hospital, Liverpool; University of Aberdeen, Aberdeen, UK; Center for Medical Imaging, University of Groningen, Groningen; Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands; and Department of Thoracic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Journal ArticleDOI
Non–Small Cell Lung Cancer
David S. Ettinger,Wallace Akerley,Gerold Bepler,Andrew C. Chang,Richard T. Cheney,Lucian R. Chirieac,Thomas A. D'Amico,Todd L. Demmy,Steven J. Feigenberg,Robert A. Figlin,Ramaswamy Govindan,Frederic W. Grannis,Thierry Jahan,Mohammad Jahanzeb,Anne Kessinger,Ritsuko Komaki,Mark G. Kris,Corey J. Langer,Quynh-Thu Le,Renato G. Martins,Gregory A. Otterson,Jyoti D. Patel,Francisco Robert,David J. Sugarbaker,Douglas E. Wood +24 more
TL;DR: In 2010, approximately 222,520 new cases of lung or bronchial cancer will be diagnosed in the USA, and 157,300 patients are expected to die of this disease as discussed by the authors.
Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data
TL;DR: Preoperative chemotherapy significantly improves overall survival, time to distant recurrence, and recurrence-free survival in resectable NSCLC, and the findings suggest this is a valid treatment option for most of these patients.
Journal ArticleDOI
Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate endpoint.
Matthew D. Hellmann,Jamie E. Chaft,William N. William,Valerie W. Rusch,Katherine M.W. Pisters,Neda Kalhor,Apar Pataer,William D. Travis,Stephen G. Swisher,Mark G. Kris +9 more
TL;DR: This work supports the incorporation of major pathological response as a surrogate endpoint for survival in future neoadjuvant trials of resectable lung cancers, and meets criteria for a surrogate.
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TL;DR: Cisplatin-based adjuvant chemotherapy improves survival among patients with completely resected non-small-cell lung cancer and had a significantly higher survival rate than those assigned to observation.
Journal ArticleDOI
Lung Adjuvant Cisplatin Evaluation: A Pooled Analysis by the LACE Collaborative Group
Jean Pierre Pignon,Hélène Tribodet,Giorgio V. Scagliotti,Jean-Yves Douillard,Frances A. Shepherd,Richard J. Stephens,Ariane Dunant,Valter Torri,Rafael Rosell,Lesley Seymour,Stephen G. Spiro,Estelle Rolland,Roldano Fossati,Delphine Aubert,Keyue Ding,David A. Waller,Thierry Le Chevalier +16 more
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Journal ArticleDOI
Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]) : a randomised controlled trial
Jean-Yves Douillard,Rafael Rosell,Mario De Lena,Francesco Carpagnano,Rodryg Ramlau,Jose Luis Gonzáles-Larriba,Tomasz Grodzki,José Rodrigues Pereira,Alain Le Groumellec,Vito Lorusso,Claude Clary,Antoni Torres,Jabrail Dahabreh,Pierre Jean Souquet,Julio Astudillo,Pierre Fournel,Angel Artal-Cortes,Jacek Jassem,Leona Koubkova,Patricia His,Marcello Riggi,Patrick Hurteloup +21 more
TL;DR: Adjuvant vinorelbine plus cisplatin extends survival in patients with completely resected NSCLC, better defining indication of adjuvant chemotherapy.
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