Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Johan Vansteenkiste,Dirk De Ruysscher,Wilfried Eberhardt,Eric Lim,Suresh Senan,Enriqueta Felip,Solange Peters +6 more
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The Clatterbridge Cancer Centre and Liverpool Heart and Chest Hospital, Liverpool; University of Aberdeen, Aberdeen, UK; Center for Medical Imaging, University of Groningen, Groningen; Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands; and Department of Thoracic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.About:
This article is published in Annals of Oncology.The article was published on 2013-10-01 and is currently open access. It has received 1498 citations till now. The article focuses on the topics: non-small cell lung cancer (NSCLC) & Lung cancer.read more
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Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer
Scott J. Antonia,A. Villegas,Davey B. Daniel,David Vicente,Shuji Murakami,Rina Hui,Takashi Yokoi,Alberto Chiappori,Ki Hyeong Lee,Maike de Wit,Byoung Chul Cho,M. Bourhaba,Xavier Quantin,Takaaki Tokito,Tarek Mekhail,David Planchard,Young-Chul Kim,Christos S. Karapetis,Sandrine Hiret,Gyula Ostoros,Kaoru Kubota,Jhanelle E. Gray,Luis Paz-Ares,Javier de Castro Carpeño,Catherine Wadsworth,Giovanni Melillo,Haiyi Jiang,Y. Huang,Phillip A. Dennis,Mustafa Ozguroglu,Pacific Investigators +30 more
TL;DR: Progression‐free survival was significantly longer with durvalumab than with placebo, and safety was similar between the groups, and the secondary end points also favored durvalsumab.
Journal ArticleDOI
Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial.
Enriqueta Felip,Nasser K. Altorki,Caicun Zhou,Tibor Csőszi,Ihor Vynnychenko,Oleksandr Goloborodko,Alexander Luft,Andrey Akopov,Alex Martinez-Marti,Hirotsugu Kenmotsu,Yuh-Min Chen,Antonio Chella,Shunichi Sugawara,David Voong,Fan Wu,Jing Yi,Yu Deng,Mark McCleland,Elizabeth Bennett,Barbara J. Gitlitz,Heather A. Wakelee,IMpower Investigators +21 more
TL;DR: The IMpower010 trial as mentioned in this paper evaluated adjuvant atezolizumab versus best supportive care (observation and regular scans for disease recurrence) in patients with early-stage non-small-cell lung cancer.
Journal ArticleDOI
European position statement on lung cancer screening
Matthijs Oudkerk,Anand Devaraj,Rozemarijn Vliegenthart,Thomas Henzler,Helmut Prosch,Claus P. Heussel,Claus P. Heussel,Gorka Bastarrika,Nicola Sverzellati,Mario Mascalchi,Stefan Delorme,David R Baldwin,Matthew E.J. Callister,Nikolaus Becker,Marjolein A Heuvelmans,Witold Rzyman,Maurizio Infante,Ugo Pastorino,Jesper Holst Pedersen,Eugenio Paci,Stephen W. Duffy,Harry J. de Koning,John K. Field +22 more
TL;DR: A risk stratification approach should be used for future lung cancer low-dose CT programmes and patients should be provided with information on the benefits and harms of screening to ensure that patients receive the most appropriate treatment.
Journal ArticleDOI
2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up
Johan Vansteenkiste,L. Crinò,Christophe Dooms,Jean-Yves Douillard,Corinne Faivre-Finn,Eric Lim,Gaetano Rocco,Suresh Senan,P. Van Schil,Giulia Veronesi,R. Stahel,Solange Peters,Enriqueta Felip,Keith M. Kerr,Benjamin Besse,Wilfried Eberhardt,Martin J. Edelman,Tony Mok,Kenneth J. O'Byrne,Silvia Novello,Lukas Bubendorf,Antonio Marchetti,Paul Baas,Martin Reck,Konstantinos N. Syrigos,Luis Paz-Ares,Egbert F. Smit,Peter Meldgaard,Alex A. Adjei,Marianne Nicolson,Walter Weder,Dirk De Ruysscher,Cécile Le Péchoux,Paul De Leyn,Virginie Westeel +34 more
TL;DR: A total of 35 experts met to address several questions on non-small-cell lung cancer (NSCLC) in each of four areas: pathology and molecular biomarkers, first-line/second and further lines in advanced disease, early-stage disease and locally advanced disease.
Journal ArticleDOI
Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial
Mariano Provencio,Ernest Nadal,A. Insa,M.-R. García-Campelo,Joaquín Casal-Rubio,Manuel Domine,Margarita Majem,Delvys Rodriguez-Abreu,Alex Martinez-Marti,Javier de Castro Carpeño,Manuel Cobo,Guillermo López Vivanco,Edel del Barco,Reyes Bernabe Caro,Nuria Viñolas,Isidoro Barneto Aranda,Santiago Viteri,E. Pereira,Ana Royuela,M. Casarrubios,Clara Salas Antón,Edwin Roger Parra,Ignacio I. Wistuba,Virginia Calvo,Raquel Laza-Briviesca,Atocha Romero,Bartomeu Massuti,Alberto Cruz-Bermúdez +27 more
TL;DR: The results support the addition of neoadjuvant nivolumab to platinum-based chemotherapy in patients with resectable stage IIIA NSCLC and could change the perception of locally advanced lung cancer as a potentially lethal disease to one that is curable.
References
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Meta-Analysis: A Constantly Evolving Research Integration Tool
TL;DR: The four articles in this special section onMeta-analysis illustrate some of the complexities entailed in meta-analysis methods and contributes both to advancing this methodology and to the increasing complexities that can befuddle researchers.
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TNM classification of malignant tumours
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Reduced lung-cancer mortality with low-dose computed tomographic screening.
Denise R. Aberle,Amanda M. Adams,Christine D. Berg,William C. Black,Jonathan D. Clapp,Richard M. Fagerstrom,Ilana F. Gareen,Constantine Gatsonis,Pamela M. Marcus,JoRean D. Sicks +9 more
TL;DR: Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.
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International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma
William D. Travis,Elisabeth Brambilla,Masayuki Noguchi,Andrew G. Nicholson,Kim R. Geisinger,Yasushi Yatabe,David G. Beer,Charles A. Powell,Gregory J. Riely,Paul Van Schil,Kavita Garg,John H. M. Austin,Hisao Asamura,Valerie W. Rusch,Fred R. Hirsch,Giorgio V. Scagliotti,Tetsuya Mitsudomi,Rudolf M. Huber,Yuichi Ishikawa,James R. Jett,Montserrat Sanchez-Cespedes,Jean-Paul Sculier,Takashi Takahashi,Masahiro Tsuboi,Johan Vansteenkiste,Ignacio I. Wistuba,Pan-Chyr Yang,Denise R. Aberle,Christian Brambilla,Douglas B. Flieder,Wilbur A. Franklin,Adi F. Gazdar,Michael K. Gould,Philip S. Hasleton,Douglas W. Henderson,Bruce E. Johnson,David A Johnson,Keith M. Kerr,Keiko Kuriyama,Jin Soo Lee,Vincent A. Miller,Iver Petersen,Victor L. Roggli,Rafael Rosell,Nagahiro Saijo,Erik Thunnissen,M. Tsao,David Yankelewitz +47 more
TL;DR: This new adenocarcinoma classification is needed to provide uniform terminology and diagnostic criteria, especially for bronchioloalveolar carcinoma (BAC), the overall approach to small nonresection cancer specimens, and for multidisciplinary strategic management of tissue for molecular and immunohistochemical studies.
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The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours.
Peter Goldstraw,John Crowley,Kari Chansky,Dorothy J. Giroux,Patti A. Groome,Ramón Rami-Porta,Pieter E. Postmus,Valerie W. Rusch,Leslie H. Sobin +8 more
TL;DR: Suggestions include additional cutoffs for tumor size, with tumors >7 cm moving from T2 to T3; reassigning the category given to additional pulmonary nodules in some locations; and reclassifying pleural effusion as an M descriptor.
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Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer
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