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Recent advances in lab-on-a-chip for biosensing applications

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TLDR
In the context of this review, sensor designs are often fairly advanced, whereas the lab-on-a-chip aspect is still rather simplistic in many cases, albeit already offering significant improvements to existing methods.
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This article is published in Biosensors and Bioelectronics.The article was published on 2016-02-15. It has received 203 citations till now.

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Citations
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Journal ArticleDOI

Detection principles of biological and chemical FET sensors.

TL;DR: The fundamental detection principle governing every potentiometric sensor is introduced, and different state-of-the-art FET sensor structures are reviewed, followed by an analysis of electrolyte interfaces and their influence on sensor operation.
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Detection of COVID-19: A review of the current literature and future perspectives.

TL;DR: This review provides general guidelines for both scientists in the biosensing research community and the biosensor industry to develop a highly sensitive and accurate point-of-care CO VID-19 detection system, which would be of enormous benefit for controlling the current COVID-19 pandemic.
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A Survey on the Roles of Communication Technologies in IoT-Based Personalized Healthcare Applications

TL;DR: This paper surveys emerging healthcare applications, including detailed technical aspects required for the realization of a complete end-to-end solution for each application and a detailed exploration from the existing to the emerging technologies and standards that would enable such applications.
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A review of sorting, separation and isolation of cells and microbeads for biomedical applications: microfluidic approaches.

TL;DR: The mechanisms behind microfluidic techniques developed for sorting, separation, and isolation of cells and microparticles for biomedical applications are thoroughly explained and the applications in which these techniques have been adopted are reviewed.
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An overview on enzyme-mimicking nanomaterials for use in electrochemical and optical assays

TL;DR: In this paper, an overview of the analytical potential of nanomaterials is presented, which is divided into sections according to their intrinsic nature, non-enzymatic sensor designs (including electrochemical, colorimetric, fluorescent and chemiluminescent methods), and (c), applications of nonenzymatic sensors in the biomedical, environmental and food analysis fields.
References
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Journal ArticleDOI

Sensitive optical biosensors for unlabeled targets: a review.

TL;DR: This article reviews the recent progress in optical biosensors that use the label-free detection protocol, in which biomolecules are unlabeled or unmodified, and are detected in their natural forms, and focuses on the optical biosENSors that utilize the refractive index change as the sensing transduction signal.
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Electrochemical Biosensors - Sensor Principles and Architectures

TL;DR: In this article, the most common traditional traditional techniques, such as cyclic voltammetry, chronoamperometry, chronopotentiometry, impedance spectroscopy, and various field-effect transistor based methods are presented along with selected promising novel approaches, including nanowire or magnetic nanoparticle-based biosensing.
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Comparative advantages of mechanical biosensors

TL;DR: The general issues that will be critical to the success of any type of next-generation mechanical biosensor are explained, such as the need to improve intrinsic device performance, fabrication reproducibility and system integration, and the need for a greater understanding of analyte-sensor interactions on the nanoscale.
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Making it stick: convection, reaction and diffusion in surface-based biosensors.

TL;DR: This work develops a physically intuitive and practical understanding of analyte transport for researchers who develop and employ biosensors based on surface capture, and derives order-of-magnitude estimates for fundamental quantities of interest, such as fluxes, collection rates and equilibration times.
Journal ArticleDOI

Nanomaterials for biosensing applications: a review

TL;DR: This review summarizes in a non-exhaustive way the advantages of nanomaterials by focusing on nano-objects which provide further beneficial properties than “just” an enhanced surface area.
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