Journal ArticleDOI
Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers
Li Gan,Jing Wang,Jing Wang,Min Jiang,Min Jiang,Hanah Bartlett,Defang Ouyang,Frank Eperjesi,Jianping Liu,Yong Gan +9 more
TLDR
In this review, the advantages of lipid-based nanocarriers as non-invasive topical ocular drug delivery systems are presented and many systems, including emulsions, liposome, cubosomes, niosomes and other lipid- based nanoccarriers are reviewed.About:
This article is published in Drug Discovery Today.The article was published on 2013-03-01. It has received 214 citations till now. The article focuses on the topics: Nanocarriers & Drug delivery.read more
Citations
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Journal ArticleDOI
TFOS DEWS II Management and Therapy Report
Lyndon Jones,Laura E Downie,Donald R. Korb,Jose M. Benitez-del-Castillo,Reza Dana,Sophie X. Deng,Pham N. Dong,Gerd Geerling,Richard Y Hida,Yang Liu,Kyoung Yul Seo,Joseph Tauber,Tais Hitomi Wakamatsu,Jianjiang Xu,James S. Wolffsohn,Jennifer P. Craig +15 more
TL;DR: It became clear that many of the treatments available for the management of dry eye disease lack the necessary Level 1 evidence to support their recommendation, often due to a lack of appropriate masking, randomization or controls and in some cases due to issues with selection bias or inadequate sample size.
Journal ArticleDOI
Nanostructured lipid carriers: Promising drug delivery systems for future clinics.
Ana Beloqui,María Ángeles Solinís,Alicia Rodríguez-Gascón,António J. Almeida,Véronique Préat +4 more
TL;DR: The understanding of the nanostructured lipid carriers (NLC)-based formulations has improved with continuing research recently, and the result has seen an increase in the use of these in the clinical setting.
Journal ArticleDOI
Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review
TL;DR: The benefit of the incorporation of mucoadhesive polymers into the structure of these innovative pharmaceutical products to prolong their residence time in the administration site and the release of the drug cargo will be discussed with focus in the developments of the last decade.
Journal ArticleDOI
Nanoparticles and nanofibers for topical drug delivery.
TL;DR: This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery and provides significant evidence that this area of research has - and will continue to have - a profound impact on both clinical outcomes and the development of new products.
Journal ArticleDOI
In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations.
TL;DR: The recent use of biodegradable and biocompatible polymers in colloidal carrier systems has proved to be the most effective strategy, resulting in the exponential increase of the bioavailability of the ophthalmic drugs.
References
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Journal ArticleDOI
Prevalence of and Risk Factors for Dry Eye Syndrome
TL;DR: Several factors, such as smoking, caffeine use, and multivitamin use, could be studied for preventive or therapeutic efficacy in a population-based cohort to examine risk factors for the prevalence of dry eye syndrome.
Journal ArticleDOI
The use of mucoadhesive polymers in ocular drug delivery.
TL;DR: In the present update on mucoadhesive ocular dosage forms, the tremendous advances in the biochemistry of mucins, the development of new polymers, the use of drug complexes and other technological advances are discussed.
Journal Article
Determination of tear volume and tear flow.
TL;DR: The dynamics of tear flow is studied for human subjects using fluorescein as an indicator and the tear volume was found to increase with increasing tear flow, and the normal tear volume with a normal tear flow was estimated from the volume-flow relationship.
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Topical and systemic drug delivery to the posterior segments.
TL;DR: The constraints and challenges of drug delivery to the posterior segment are investigated, and several potential absorption pathways that may potentially be exploited to deliver drug to the back of the eye are outlined.
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A patient questionnaire approach to estimating the prevalence of dry eye symptoms in patients presenting to optometric practices across Canada
TL;DR: The prevalence of patients reporting any level of symptoms of dry eyes was approximately 1 in 4; severe symptoms were reported by 1 in 225 patients.