Pierre Renault

TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.

TL;DR: MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance.

TL;DR: The authors' classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.

TL;DR: Diet-induced weight-loss and weight-stabilization interventions in a study sample of obese and overweight individuals are conducted and it is reported that individuals with reduced microbial gene richness present more pronounced dys-metabolism and low-grade inflammation.

TL;DR: In this paper, the authors evaluated the association between faecal A. muciniphila abundance and microbial gene richness after calorie restriction (CR) in overweight and obese adults.