Journal ArticleDOI
Regio- and enantioselective Pd-catalyzed allylic alkylation of ketones through allyl enol carbonates.
Barry M. Trost,Jiayi Xu +1 more
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TLDR
The Pd-catalyzed reorganization of enol allyl carbonates to allylated ketones occurs asymmetrically in the presence of chiral ligands previously developed in this group, and for the first time, asymmetric creation of tertiary centers occurs with high ee.Abstract:
The Pd-catalyzed reorganization of enol allyl carbonates to allylated ketones occurs asymmetrically in the presence of chiral ligands previously developed in this group. With 2-methylcyclohexanone,...read more
Citations
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Palladium-catalyzed cross-coupling reactions in total synthesis.
TL;DR: In this Review, highlights of a number of selected syntheses are discussed, demonstrating the enormous power of these processes in the art of total synthesis and underscore their future potential in chemical synthesis.
Journal ArticleDOI
Metal-catalyzed enantioselective allylation in asymmetric synthesis.
TL;DR: Metal-catalyzed enantioselective allylation, which involves the substitution of allylic metal intermediates with a diverse range of different nucleophiles or S(N)2'-type allylic substitution, leads to the formation of C-H, -C, -O, -N, -S, and other bonds with very high levels of asymmetric induction.
Journal ArticleDOI
Transition Metal-Catalyzed Decarboxylative Allylation and Benzylation Reactions
TL;DR: Transition metal catalyzed decarboxylative allylation, benzylations, and interceptive allylations are reviewed.
Journal ArticleDOI
Catalytic enantioselective synthesis of quaternary carbon stereocentres
TL;DR: The many catalytic enantioselective reactions developed during the past decade for the synthesis of single stereoisomers of such organic molecules make it possible to incorporate quaternary stereocentres selectively in many organic molecules that are useful in medicine, agriculture and potentially other areas such as flavouring, fragrances and materials.
Journal ArticleDOI
Palladiumkatalysierte Kreuzkupplungen in der Totalsynthese
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Paul G. Bulger,Paul G. Bulger,David Sarlah,David Sarlah +5 more
TL;DR: In this paper, the authors discuss the effect of leistungsfahigen Reaktionen on the Potenzial f f zukunftige chemischen Synthesen unterstreichen, i. e.g., palladiumkatalysierten Kreuzkupplungen.
References
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Journal ArticleDOI
The Enantioselective Tsuji Allylation
TL;DR: The first catalytic enantioselective examples of the Tsuji allylation using enol carbonates and enol silanes are described and are useful building blocks for synthetic chemistry.
Journal ArticleDOI
Palladium-Catalyzed Asymmetric Alkylation of Ketone Enolates
Journal ArticleDOI
Asymmetric allylic alkylation of ketone enolates: an asymmetric Claisen surrogate.
Erin C. Burger,Jon A. Tunge +1 more
TL;DR: The combination of catalytic palladium(0) and Trost ligand provides an effective catalyst for the rearrangement of allyl beta-ketoesters and allows regiospecific generation of enolates under extremely mild conditions.