Journal ArticleDOI
Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control
Daniel J. Lew,Sally Kornbluth +1 more
Reads0
Chats0
TLDR
This work has uncovered new and unexpected potential roles, and prompted re-examination of previously assumed roles, of Cdk phosphorylation, and identified many of the enzymes that act on these sites.About:
This article is published in Current Opinion in Cell Biology.The article was published on 1996-12-01. It has received 340 citations till now. The article focuses on the topics: Cyclin-dependent kinase & CDK-activating kinase.read more
Citations
More filters
Journal ArticleDOI
The Ki‐67 protein: From the known and the unknown
Thomas Scholzen,Johannes Gerdes +1 more
TL;DR: Although the Ki‐67 protein is well characterized on the molecular level and extensively used as a proliferation marker, the functional significance still remains unclear; there are indications, however, that Ki‐ 67 protein expression is an absolute requirement for progression through the cell‐division cycle.
Journal ArticleDOI
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
Jirina Bartkova,Zuzana Horejsi,Karen Koed,Alwin Krämer,Frederic Tort,Karsten Zieger,Per Guldberg,Maxwell Sehested,Jahn M. Nesland,Claudia Lukas,Torben F. Ørntoft,Jiri Lukas,Jiri Bartek +12 more
TL;DR: It is shown that in clinical specimens from different stages of human tumours of the urinary bladder, breast, lung and colon, the early precursor lesions commonly express markers of an activated DNA damage response.
Journal ArticleDOI
Cyclin-dependent kinases: engines, clocks, and microprocessors.
TL;DR: This work has shown that Cdk activity is governed by a complex network of regulatory subunits and phosphorylation events whose precise effects on Cdk conformation have been revealed by recent crystallographic studies.
Journal ArticleDOI
The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer
TL;DR: This review provides an overview of deregulation of the cell cycle in cancer by focusing on mechanisms, i.e. regulation of cyclin‐dependent kinases (CDK) by cyclins, CDK inhibitors and phosphorylating events.
Journal ArticleDOI
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.
TL;DR: Results indicate that serine-216 phosphorylation and 14-3-3 binding negatively regulate Cdc25C and identify CDC25C as a potential target of checkpoint control in human cells.
References
More filters
Journal ArticleDOI
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
TL;DR: The purification and identification of the factors necessary for the E6-E6-AP-mediated ubiquitination of p53 are reported, and E 6-AP appears to have ubiquitin-protein ligase activity in the absence of E6.
Journal ArticleDOI
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog
Paul Russell,Paul Nurse +1 more
TL;DR: Fission yeast wee1- mutants initiate mitosis at half the cell size of wild type and functions as a dose-dependent inhibitor of mitosis, the first such element to be specifically identified and cloned.
Journal ArticleDOI
cdc25+ functions as an inducer in the mitotic control of fission yeast.
Paul Russell,Paul Nurse +1 more
TL;DR: Evidence is described showing that cdc25+ functions to counteract the activity of the mitotic inhibitor wee1+, and indicating that both mitotic control elements act independently to regulate the initiation of mitosis.
Journal ArticleDOI
Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase.
TL;DR: Results indicate that the product of the WEE1Hu gene directly regulates the p34cdc2-cyclin B complex in human cells and that a kinase other than that encoded by WEE2Hu phosphorylates p34CDc2 on threonine 14.
Journal ArticleDOI
Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15
TL;DR: Immunodepletion studies suggested that Myt1 is the predominant threonine-14-specific kinase in Xenopus egg extracts, suggesting that this relative of Wee1 plays a role in mitotic control.