Journal ArticleDOI
Relationship between insulin sensitivity, insulin secretion and glucose tolerance in cirrhosis.
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TLDR
C‐peptide and insulin secretion rates after a 75‐gm oral glucose load and during a 10 mmol/L hyperglycemic clamp are derived and cirrhotic patients were confirmed as insulin‐insensitive during a euglycemic clamp.About:
This article is published in Hepatology.The article was published on 1991-07-01. It has received 138 citations till now. The article focuses on the topics: Insulin & Glucose tolerance test.read more
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Journal ArticleDOI
Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis
Rami Moucari,Tarik Asselah,Dominique Cazals–Hatem,Hélène Voitot,Nathalie Boyer,Marie Pierre Ripault,Rodolphe Sobesky,Michele Martinot Peignoux,Sarah Maylin,Marie Hélène Nicolas–Chanoine,Valérie Paradis,Michel Vidaud,Dominique Valla,Pierre Bedossa,Patrick Marcellin +14 more
TL;DR: IR is a specific feature of chronic hepatitis C, associated with genotypes 1 and 4 and high serum HCV RNA level and significant fibrosis is associated with IR independent from steatosis.
Journal ArticleDOI
Insulin sensitivity and its measurement: structural commonalities among the methods.
TL;DR: Most methods used in the assessment of insulin sensitivity examine the response to insulin of a single metabolite, glucose, primarily in the muscle and liver, and under fasting conditions and should, therefore, demonstrate insulin sensitivity that is comparable among methods.
CLINICAL REVIEW 119 Insulin Sensitivity and Its Measurement: Structural Commonalities among the Methods*
TL;DR: Most methods used in the assessment of insulin sensitivity examine the response to insulin of a single metabolite, glucose, primarily in the muscle and liver, and under fasting conditions and should, therefore, demonstrate insulin sensitivity that is comparable among methods as mentioned in this paper.
Journal ArticleDOI
Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis
TL;DR: In conclusion, diabetes mellitus in insulinresistant cirrhotic patients develops as the result of progressive impairment in insulin secretion together with the development of hepatic insulin resistance leading to fasting hyperglycemia and a diabetic glucose tolerance profile.
Journal ArticleDOI
Prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic disease.
TL;DR: Diabetes was not associated with increased risk of rejection, retransplantation, or death at 1 year after transplantation, and had no impact on overall survival after liver transplantation.
References
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Journal ArticleDOI
Role of Insulin Resistance in Human Disease
TL;DR: The possibility is raised that resistance to insulin-stimulated glucose uptake and hyperinsulinemia are involved in the etiology and clinical course of three major related diseases— NIDDM, hypertension, and CAD.
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Glucose clamp technique: a method for quantifying insulin secretion and resistance.
TL;DR: Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique] are described.
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Glucagon-like peptide-1 7-36: a physiological incretin in man.
TL;DR: The observation of greatly increased postprandial plasma GLP-1 7-36 levels in patients with postgastrectomy dumping syndrome suggests that it may mediate the hyperinsulinaemia and reactive hypoglycaemia of this disorder.
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Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach.
TL;DR: The proposed model of insulin/C-peptide kinetics, derived from the original conception of Eaton and Polonsky, suggests that in healthy individuals, there is a balance between secretion and insulin action such that insulin secretion × insulin sensitivity = constant, and supports the concept that, at physiological insulin levels, the time for insulin to cross the capillary endothelium is the process that determines the rate of insulin action in vivo.
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Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*
TL;DR: In the noninsulin-requiring maturity-onset diabetic, the glycemic insulinogenic stimulus for a given oral glucose load is significantly greater than in normal subjects and accounts for the excessive plasma insulin responses observed late in the course of an oral glucose tolerance test.