Remote CB1 receptor antagonist administration reveals multiple sites of tonic and phasic endocannabinoid neuroendocrine regulation
Ryan J. Newsom,Robert J. Garcia,Jacob Stafford,Chad D. Osterlund,Casey E O'Neill,Heidi E.W. Day,Serge Campeau +6 more
Reads0
Chats0
TLDR
Interestingly, CB1R mRNA was rapidly and bidirectionally regulated in response to stress and/or antagonist treatment in some regions, suggesting eCBs modulate the HPA axis by regulating both constitutive and activity-dependent inhibition at multiple levels.About:
This article is published in Psychoneuroendocrinology.The article was published on 2020-03-01 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Basolateral amygdala & Stria terminalis.read more
Citations
More filters
Journal ArticleDOI
CB1 and CB2 receptors in the bed nucleus of the stria terminalis differently modulate anxiety-like behaviors in rats
Lucas Gomes-de-Souza,Paula Cristina Bianchi,Willian Costa-Ferreira,Rodrigo A. Tomeo,Fabio C. Cruz,Carlos C. Crestani,Carlos C. Crestani +6 more
TL;DR: In this article, the presence of CB1 and CB2 receptors in the stria terminalis (BNST) and their role in anxiety-like behaviors was investigated in rats.
Journal ArticleDOI
Lateral hypothalamus involvement in control of stress response by bed nucleus of the stria terminalis endocannabinoid neurotransmission in male rats.
Lucas Gomes-de-Souza,Lucas Gomes-de-Souza,Willian Costa-Ferreira,Willian Costa-Ferreira,Michelle Mendanha Mendonça,Carlos Henrique Xavier,Carlos C. Crestani,Carlos C. Crestani +7 more
TL;DR: In this paper, the role of LH GABAergic neurotransmission in the regulation of cardiovascular responses to stress by CB1 receptors within the stria terminalis (BNST) was investigated.
Journal ArticleDOI
CB1 Activity Drives the Selection of Navigational Strategies: A Behavioral and c-Fos Immunoreactivity Study.
Daniela Laricchiuta,Francesca Balsamo,Carlo Fabrizio,Anna Panuccio,Andrea Termine,Laura Petrosini +5 more
TL;DR: Light is shed on the involvement of CB1 receptors as part of the selection system of the navigational strategies implemented to efficiently solve the spatial problem.
Journal ArticleDOI
Endocannabinoid signaling as an intrinsic component of the circuits mediating adaptive responses to repeated stress exposure in adult male sprague dawley rats.
TL;DR: A progressive intensification of neural eCB signaling at CB1 receptors with repeated stress exposures is suggested, which is consistent with evidence implicates the endocannabinoid system as a negative modulator of neural and endocrine responses to acute stressors.
Journal ArticleDOI
Glucocorticoids, Stress and Delta-9 Tetrahydrocannabinol (THC) during Early Embryonic Development.
TL;DR: In this paper, the authors evaluated the results of studies which have investigated the effects of glucocorticoids on reproductive development and how THC may alter stress signaling in relevant tissues.
References
More filters
Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Protective and Damaging Effects of Stress Mediators
TL;DR: The long-term effect of the physiologic response to stress is reviewed, which I refer to as allostatic load, which is the ability to achieve stability through change.
Journal ArticleDOI
Isolation and structure of a brain constituent that binds to the cannabinoid receptor
William A. Devane,Lumir Hanus,Aviva Breuer,Roger G. Pertwee,Lesley A. Stevenson,Graeme Griffin,Dan Gibson,Asher Mandelbaum,A. Etinger,Raphael Mechoulam +9 more
TL;DR: In this article, an arachidonylethanthanolamide (anandamide) was identified in a screen for endogenous ligands for the cannabinoid receptor and its structure was determined by mass spectrometry and nuclear magnetic resonance spectroscopy and confirmed by synthesis.
Journal ArticleDOI
2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
Takayuki Sugiura,Sachiko Kondo,Akihiro Sukagawa,Shinji Nakane,A. Shinoda,K. Itoh,Atsushi Yamashita,Keizo Waku +7 more
TL;DR: 2-Arachidonoylglycerol was shown to bind appreciably to the cannabinoid receptor in competitive inhibition experiments and may be an endogenous cannabinoid receptor ligand in the brain.
Journal ArticleDOI
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
TL;DR: The results suggest that the presently characterized cannabinoid receptor mediates physiological and behavioral effects of natural and synthetic cannabinoids, because it is strongly coupled to guanine nucleotide regulatory proteins and is discretely localized to cortical, basal ganglia, and cerebellar structures involved with cognition and movement.