Journal ArticleDOI
Residual tumour hypoxia in head-and-neck cancer patients undergoing primary radiochemotherapy, final results of a prospective trial on repeat FMISO-PET imaging.
Steffen Löck,Rosalind Perrin,Annekatrin Seidlitz,Anna Bandurska-Luque,Sebastian Zschaeck,Klaus Zöphel,Mechthild Krause,Jörg Steinbach,Jörg Kotzerke,Daniel Zips,Esther G.C. Troost,Michael Baumann +11 more
TLDR
This study validates that residual tumour hypoxia during radiochemotherapy is a major driver of therapy resistance of HNSCC, and that hypoxic volume after the second week of treatment measured by FMISO-PET may serve as biomarker for selection of patients at high risk of loco-regional recurrence after state-of-the art radiochem therapy.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-09-01. It has received 109 citations till now. The article focuses on the topics: Head and neck squamous-cell carcinoma.read more
Citations
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Journal ArticleDOI
Assessing robustness of radiomic features by image perturbation.
Alex Zwanenburg,Alex Zwanenburg,Stefan Leger,Stefan Leger,Linda Agolli,Linda Agolli,Karoline Pilz,Karoline Pilz,Esther G.C. Troost,Christian Richter,Christian Richter,Steffen Löck,Steffen Löck,Steffen Löck +13 more
TL;DR: In this article, the authors investigated 18 combinations of image perturbations to determine feature robustness, based on noise addition (N), translation (T), rotation (R), volume growth/shrinkage (V) and supervoxel-based contour randomisation (C).
Journal ArticleDOI
Modern radiotherapy for head and neck cancer.
Daniela Alterio,Giulia Marvaso,Annamaria Ferrari,Stefania Volpe,Roberto Orecchia,Barbara Alicja Jereczek-Fossa +5 more
TL;DR: The aim of the present review was to highlight modern concepts of RT for head and neck cancers considering both the technological advances that have been achieved and recent knowledge that has informed the biological interaction between radiation and both tumor and healthy tissues.
Journal ArticleDOI
HPV, hypoxia and radiation response in head and neck cancer.
TL;DR: The differences between HPV-positive and HPV-negative head and neck tumours and methods of hypoxia detection and targeting in these disease types are discussed, with particular emphasis on the mechanisms by which HPV infection impacts radiosensitivity.
Journal ArticleDOI
PET/CT in radiation oncology.
TL;DR: An overview of the basic principles of PET-based target volume selection and definition using 18F-fluorodeoxyglucose (18F-FDG) and then a focus on the emerging strategies of dose painting and adaptive radiotherapy using different tracers.
Journal ArticleDOI
Integrating molecular nuclear imaging in clinical research to improve anticancer therapy
Elisabeth G.E. de Vries,Laura Kist de Ruijter,Marjolijn N. Lub-de Hooge,Rudi Dierckx,Sjoerd G. Elias,Sjoukje F. Oosting +5 more
TL;DR: The multistage process of developing novel molecular imaging biomarkers is discussed, highlighting both the challenges that have restricted the use of molecular imaging in clinical oncology research and future opportunities in this area.
References
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Regression modeling strategies : with applications to linear models, logistic regression, and survival analysis
TL;DR: In this article, the authors present a case study in least squares fitting and interpretation of a linear model, where they use nonparametric transformations of X and Y to fit a linear regression model.
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Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer
K. Kian Ang,Jonathan Harris,Richard H. Wheeler,Randal S. Weber,David I. Rosenthal,Phuc Felix Nguyen-Tân,William H. Westra,Christine H. Chung,Richard C.K. Jordan,Charles Lu,Harold Kim,Rita Axelrod,C Craig Silverman,Kevin P. Redmond,Maura L. Gillison +14 more
TL;DR: Tumor HPV status is a strong and independent prognostic factor for survival among patients with oropharyngeal cancer and the risk of death significantly increased with each additional pack-year of tobacco smoking.
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Hypoxia in cancer: significance and impact on clinical outcome
Peter Vaupel,Arnulf Mayer +1 more
TL;DR: In this article, the authors suggest that hypoxia is prognostic for survival and local control in head and neck cancers, and use endogenous proteins (e.g., HIF-1α, GLUT-1, CA IX) or exogenous bioreductive drugs.
Journal ArticleDOI
Hypoxia and Inflammation
TL;DR: This review deals with emerging evidence of an association between systemic or local hypoxia and inflammation in a variety of diseases and points to new ways of treating inflammatory disorders or conditions such as certain cancers with intralesional Hypoxia.
Journal ArticleDOI
HPV-associated head and neck cancer: a virus-related cancer epidemic
TL;DR: In this paper, the authors highlight current understanding of the epidemiology, biology, detection, and management of HPV-related oropharyngeal head and neck squamous cell carcinoma, and describe unresolved issues.