Book ChapterDOI
Retrieval and Investigation of Data on SARS-CoV-2 and COVID-19 Using Bioinformatics Approach.
Muhamad Fahmi,Muhamad Fahmi,Viol Dhea Kharisma,Arif Nur Muhammad Ansori,Masahiro Ito,Masahiro Ito +5 more
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In this article, the authors report essential bioinformatics entities, such as database and platform development, molecular evolution and phylogenetic analyses, and vaccine designs, that are useful to solve the SARS-CoV-2 conundrum.Abstract:
Sudden emergence and a rapid outbreak of SARS-CoV-2 accompanied by a devastating impact on the economy and public health has driven extensive scientific mobilization to study and elucidate the various associated concerns about SARS-CoV-2. Bioinformatics plays a crucial role in addressing and providing solutions to questions about SARS-CoV-2. It helps shorten the duration for the vaccine development process and the discovery of potential clinical interventions through the simulation and information retrieval, and the development of well-ordered information hubs and resources, which are essential to derive data and meaningful findings from the current massive information about SARS-CoV-2. Advanced algorithms in this field also provide approaches that are essential to elucidate the relationship, origin, and evolutionary process of SARS-CoV-2. Here, we report essential bioinformatics entities, such as database and platform development, molecular evolution and phylogenetic analyses, and vaccine designs, that are useful to solve the SARS-CoV-2 conundrum.read more
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Journal ArticleDOI
Herbal combination from Moringa oleifera Lam. and Curcuma longa L. as SARS-CoV-2 antiviral via dual inhibitor pathway: A viroinformatics approach
Viol Dhea Kharisma,Aggy Agatha,Arif Nur Muhammad Ansori,Muhammad Hermawan Widyananda,Wahyu Choirur Rizky,Tim Godefridus Antonius Ding,Marina Derkho,I. Lykasova,Yulanda Antonius,Imam Rosadi,Rahadian Zainul +10 more
TL;DR: In this paper , a combination of Moringa oleifera Lam and Curcuma longa L. is predicted to have antiviral and anti-inflammatory activity through dual inhibitor mechanism played by cryptochlorogenic acid and curcumin.
Journal ArticleDOI
In Silico Screening of Bioactive Compounds from Syzygium cumini L. and Moringa oleifera L. Against SARS-CoV-2 via Tetra Inhibitors
Nur Sofiatul Aini,Viol Dhea Kharisma,Muhammad Hermawan Widyananda,Ahmad Affan Ali Murtadlo,Rasyadan Taufiq Probojati,Dora Dayu Rahma Turista,Muhammad Badrut Tamam,Vikash Jakhmola,Devni Prima Sari,Muhammad Thoriq Albari,Devi Pernamasari,Muhammad Arya Ghifari,Muhammad Raffi Ghifari,Riso Sari Mandeli,Muhardi Muhardi,Budhi Oktavia,Trisna K. Sari,Titi Sriwahyuni,Putri Azhari,Mirella Fonda Maahury,A.N.M. Ansori,Rahadian Zainul +21 more
TL;DR: Results show that ellagic acid from java plum and myricetin from moringa have the best potential as potential antivirals, and the bioactive compounds with the best antiviral potential had the lowest affinity bonds to the target proteins against RBD spike, helicase, Mpro, and RdRp of SARS-CoV-2.
Journal ArticleDOI
Bioactive Compounds from Purslane (Portulaca oleracea L.) and Star Anise (Illicium verum Hook) as SARS-CoV-2 Antiviral Agent via Dual Inhibitor Mechanism: In Silico Approach
Nur Sofiatul Aini,Viol Dhea Kharisma,Muhammad Hermawan Widyananda,Ahmad Affan Ali Murtadlo,Rasyadan Taufiq Probojati,Dora Dayu Rahma Turista,Muhammad Badrut Tamam,Vikash Jakhmola,Dony Novaliendry,Riso Sari Mandeli,Budhi Oktavia,Muhammad Thoriq Albari,Saddam Al Aziz,Muhammad Raffi Ghifari,Okta Suryani,Putri Azhari,Muhammad Arya Ghifari,Devi Purnamasari,Agariadne Dwinggo Samala,Mirella Fonda Maahury,A.N.M. Ansori,Rahadian Zainul +21 more
TL;DR: The results showed that purslane luteolin has the best antiviral potential, however, further studies are required to validate this computational prediction.
Journal ArticleDOI
Molecular Mechanism of Black Tea (Camellia sinensis) as SARS-CoV-2 Spike Glycoprotein Inhibitor through Computational Approach
TL;DR: In this paper , the authors identify the bioactive compounds from Camellia sinensis as an antiviral agent via spike glycoprotein inhibitor mechanisms against the SARS-CoV-2 infection through the in silico approach.
Journal ArticleDOI
Computational Drug Design Study of Curcuma longa L. Compound as HPV-16 Antiviral Candidate Against Cervical Cancer
TL;DR: In this paper , the authors predict the molecular mechanism and screening of drug candidate compounds in Curcuma longa L. to inhibit the activity of the human papillomavirus (HPV) E6 protein through a bioinformatics approach.
References
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