Revealing Polymorphic Phase Transformations in Polymer-Based Hot Melt Extrusion Processes.
José R. Hernández Espinell,José R. Hernández Espinell,Vilmalí López-Mejías,Vilmalí López-Mejías,Torsten Stelzer,Torsten Stelzer +5 more
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TLDR
This work demonstrates that flufenamic acid (FFA), one of the most polymorphic APIs known, thus far, can be processed using temperature-simulated HME with polyethylene glycol (PEG) as polymeric carrier and thorough understanding of the thermodynamic and kinetic design space for the PEG-FFA system leads to polymorphic control in the produced crystalline solid dispersions.Abstract:
The inadvertent occurrence of polymorphic phase transformations in active pharmaceutical ingredients (APIs) during hot melt extrusion (HME) processes has been claimed to limit the application of this technique. Hence, the control of polymorphism would need to be addressed if there is any prospect of HME to be successfully implemented as an alternative solid dosage formulation strategy in integrated, continuous end-to-end pharmaceutical manufacturing settings. This work demonstrates that flufenamic acid (FFA), one of the most polymorphic APIs known, thus far, can be processed using temperature-simulated HME with polyethylene glycol (PEG) as polymeric carrier. At temperatures above the transition point of FFA forms III and I (42 °C), the induction time of the polymorphic phase transformation is longer than the average reported residence time in conventional HME processes (5 min). Moreover, it was demonstrated that thorough understanding of the thermodynamic and kinetic design space for the PEG-FFA system le...read more
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Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment.
Aarón Martínez-Higuera,César Rodríguez-Beas,Jesús Mauro Adolfo Villalobos-Noriega,Abraham Arizmendi-Grijalva,Carlos Ochoa-Sánchez,Eduardo Larios-Rodríguez,Juan Manuel Martínez-Soto,Ericka Rodríguez-León,Cristina Ibarra-Zazueta,Roberto Mora-Monroy,H.A. Borbón-Nuñez,Alfonso García-Galaz,Maria del Carmen Candia-Plata,Luis Fernando López-Soto,Ramón Iñiguez-Palomares +14 more
TL;DR: In this paper, the authors used Mimosa tenuiflora (MtE) extracts as reducing agents to synthesize silver nanoparticles (AgMt NPs) which were characterized by DPPH and Total Polyphenols Assays, UV-visible, X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HRTEM), XPS, and Thermogravimetric analysis (TGA).
Journal ArticleDOI
Coprocessing of pharmaceutical cocrystals for high quality and enhanced physicochemical stability
TL;DR: In this paper, solid state synthesis of high quality indomethacin-saccharin cocrystals was achieved using hot melt extrusion and coprocessing with inert excipients at the final kneading zone.
Journal ArticleDOI
Polymorphic Phase Transformation Pathways under Nanoconfinement: Flufenamic Acid
Keke Zhang,Keke Zhang,Noalle Fellah,Vilmalí López-Mejías,Vilmalí López-Mejías,Michael D. Ward +5 more
TL;DR: Flufenamic acid (FFA) is a highly polymorphic compound, with nine forms to date as discussed by the authors, and when melt crystallization was performed under nanoscale confinement in controlled pore glass (CPG), the formation of...
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Analysis and ANN Prediction of Melting Properties and Ideal Mole fraction Solubility of Co-crystals
TL;DR: Different Artificial Neural Network models have been developed and examined for prediction of cocrystal properties based on pure component physical properties only as mentioned in this paper, from the molecular weight, melting point, etc.
References
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Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.