Open AccessJournal Article
Revisiting the hallmarks of cancer.
Yousef A. Fouad,Carmen Aanei +1 more
TLDR
This work defines seven hallmarks of cancer: selective growth and proliferative advantage, altered stress response favoring overall survival, vascularization, invasion and metastasis, metabolic rewiring, an abetting microenvironment, and immune modulation, while highlighting some considerations for the future of the field.Abstract:
The hallmarks of cancer described by Hanahan and Weinberg have proved seminal in our understanding of cancer's common traits and in rational drug design. Not free of critique and with understanding of different aspects of tumorigenesis coming into clearer focus in the recent years, we attempt to draw a more organized and updated picture of the cancer hallmarks. We define seven hallmarks of cancer: selective growth and proliferative advantage, altered stress response favoring overall survival, vascularization, invasion and metastasis, metabolic rewiring, an abetting microenvironment, and immune modulation, while highlighting some considerations for the future of the field.read more
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Molecular principles of metastasis: a hallmark of cancer revisited
Jawad Fares,Jawad Fares,Mohamad Y. Fares,Mohamad Y. Fares,Hussein H. Khachfe,Hussein H. Khachfe,Hamza A. Salhab,Hamza A. Salhab,Youssef Fares +8 more
TL;DR: The authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer.
Journal ArticleDOI
Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics.
Rehmat Jan,Gul-e-Saba Chaudhry +1 more
TL;DR: This review focused on the underlying mechanism of apoptosis and the dysregulation of apoptotic modulators involved in the extrinsic and intrinsic apoptotic pathway, which include death receptors (DRs) proteins, cellular FLICE inhibitory proteins (c-FLIP), anti-apoptotic Bcl-2 proteins, inhibitors of apoptOS proteins (IAPs), tumor suppressor (p53) in cancer cells along with various current clinical approaches aimed to selectively induce apoptosis.
Journal ArticleDOI
Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome.
Simona Mihai,Elena Codrici,Ionela Daniela Popescu,Ana-Maria Enciu,Lucian Albulescu,Laura Necula,Cristina Mambet,Gabriela Anton,Cristiana Tanase +8 more
TL;DR: The recent knowledge regarding the relationship between inflammation and CKD is summarized, highlighting the current proteomic approaches, as well as the inflammasomes and gut microbiota dysbiosis involvement in the setting of CKD, culminating with the troubling bidirectional connection between CKD and renal malignancy.
Journal ArticleDOI
Fanconi anaemia and cancer: an intricate relationship.
Grzegorz Nalepa,D. Wade Clapp +1 more
TL;DR: How theFA pathway safeguards genome integrity throughout the cell cycle is discussed and how studies of FA have revealed opportunities to develop rational therapeutics for this genetic disease and for malignancies that acquire somatic mutations within the FA pathway are shown.
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
Jared R. Mayers,Margaret E. Torrence,Laura V. Danai,Thales Papagiannakopoulos,Shawn M. Davidson,Matthew R. Bauer,Allison N. Lau,Brian W. Ji,Purushottam D. Dixit,Aaron M. Hosios,Alexander Muir,Christopher R. Chin,Elizaveta Freinkman,Tyler Jacks,Brian M. Wolpin,Dennis Vitkup,M. G. Vander Heiden +16 more
TL;DR: Loss of Bcat1 and Bcat2, the enzymes responsible for BCAA use, impairs NSCLC tumor formation, but these enzymes are not required for PDAC tumorformation, arguing that tissue of origin is an important determinant of how cancers satisfy their metabolic requirements.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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The biology of VEGF and its receptors.
TL;DR: Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions and is implicated in pathologicalAngiogenesis associated with tumors, intraocular neovascular disorders and other conditions.