Journal ArticleDOI
Roadmap to embryo implantation: clues from mouse models
Haibin Wang,Sudhansu K. Dey +1 more
TLDR
A better understanding of periimplantation biology could alleviate female infertility and help to develop novel contraceptives and the future challenges of the field are highlighted.Abstract:
Implantation involves an intricate discourse between the embryo and uterus and is a gateway to further embryonic development. Synchronizing embryonic development until the blastocyst stage with the uterine differentiation that takes place to produce the receptive state is crucial to successful implantation, and therefore to pregnancy outcome. Although implantation involves the interplay of numerous signalling molecules, the hierarchical instructions that coordinate the embryo-uterine dialogue are not well understood. This review highlights our knowledge about the molecular development of preimplantation and implantation and the future challenges of the field. A better understanding of periimplantation biology could alleviate female infertility and help to develop novel contraceptives.read more
Citations
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Journal ArticleDOI
Mechanisms of implantation: strategies for successful pregnancy
TL;DR: Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization.
Journal ArticleDOI
Inflammation and pregnancy: the role of the immune system at the implantation site.
TL;DR: A new paradigm in terms of the fetal–maternal immune interaction as well as the immunological response of the mother to microorganism is proposed in order to better understand the immunology of pregnancy and to deliver the appropriate treatment to patients with pregnancy complications.
Journal ArticleDOI
Cyclic decidualization of the human endometrium in reproductive health and failure.
Birgit Gellersen,Jan J. Brosens +1 more
TL;DR: The endocrine, paracrine, and autocrine cues that tightly govern this differentiation process are reviewed and how disorders that subvert the programming, initiation, or progression of decidualization compromise reproductive health and predispose for pregnancy failure is discussed.
Journal ArticleDOI
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos
Xiaoyu Liu,Chenfei Wang,Wenqiang Liu,Jingyi Li,Chong Li,Xiaochen Kou,Jiayu Chen,Yanhong Zhao,Haibo Gao,Hong Wang,Yong Zhang,Yawei Gao,Shaorong Gao,Shaorong Gao +13 more
TL;DR: A small-scale chromatin immunoprecipitation followed by sequencing method is used to map the genome-wide profiles of histone H3 lysine 4 trimethylation (H3K4me3) and H3K27me3, which are associated with gene activation and repression, respectively, in mouse pre-implantation embryos, facilitating further exploration of the mechanism for epigenetic regulation in early embryos.
Journal ArticleDOI
Physiological and molecular determinants of embryo implantation
Shuang Zhang,Hai-Yan Lin,Shuangbo Kong,Shumin Wang,Hongmei Wang,Haibin Wang,D. Randall Armant,D. Randall Armant +7 more
TL;DR: A better understanding of underlying mechanisms governing embryo implantation should generate new strategies to rectify implantation failure and improve pregnancy rates in women.
References
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Journal ArticleDOI
Core transcriptional regulatory circuitry in human embryonic stem cells.
Laurie A. Boyer,Tong Ihn Lee,Megan F. Cole,Sarah E. Johnstone,Stuart S. Levine,Jacob P. Zucker,Matthew G. Guenther,Roshan M. Kumar,Heather L. Murray,Richard G. Jenner,David K. Gifford,David K. Gifford,David K. Gifford,Douglas A. Melton,Douglas A. Melton,Rudolf Jaenisch,Richard A. Young,Richard A. Young +17 more
TL;DR: Insight is provided into the transcriptional regulation of stem cells and how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal and how they collaborate to form regulatory circuitry consisting of autoregulatory and feedforward loops.
Journal ArticleDOI
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells.
TL;DR: A role is established for Oct-3/4 as a master regulator of pluripotency that controls lineage commitment and the sophistication of critical transcriptional regulators is illustrated and the consequent importance of quantitative analyses are illustrated.
Journal ArticleDOI
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
Jennifer Nichols,Branko Zevnik,Konstantinos Anastassiadis,Hitoshi Niwa,Daniela Klewe-Nebenius,Ian Chambers,Hans R. Schöler,Austin Smith +7 more
TL;DR: It is reported that the activity of Oct4 is essential for the identity of the pluripotential founder cell population in the mammalian embryo and also determines paracrine growth factor signaling from stem cells to the trophectoderm.
Journal ArticleDOI
Functional expression cloning of nanog, a pluripotency sustaining factor in embryonic stem cells
Ian Chambers,Douglas Colby,Morag Robertson,Jennifer Nichols,Sonia Lee,Susan Tweedie,Austin Smith +6 more
TL;DR: These findings establish a central role for Nanog in the transcription factor hierarchy that defines ES cell identity and confirm that Cytokine dependence, multilineage differentiation, and embryo colonization capacity are fully restored upon transgene excision.
Journal ArticleDOI
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
Kaoru Mitsui,Yoshimi Tokuzawa,Hiroaki Itoh,Kohichi Segawa,Mirei Murakami,Kazutoshi Takahashi,Masayoshi Maruyama,Mitsuyo Maeda,Shinya Yamanaka +8 more
TL;DR: Nanog is a critical factor underlying pluripotency in both ICM and ES cells, and it is found that one of them, encoding the homeoprotein Nanog, was capable of maintaining ES cell self-renewal independently of LIF/Stat3.