Physiological and molecular determinants of embryo implantation
Shuang Zhang,Hai-Yan Lin,Shuangbo Kong,Shumin Wang,Hongmei Wang,Haibin Wang,D. Randall Armant,D. Randall Armant +7 more
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TLDR
A better understanding of underlying mechanisms governing embryo implantation should generate new strategies to rectify implantation failure and improve pregnancy rates in women.About:
This article is published in Molecular Aspects of Medicine.The article was published on 2013-10-01 and is currently open access. It has received 397 citations till now. The article focuses on the topics: Blastocyst & Decidualization.read more
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Cyclic decidualization of the human endometrium in reproductive health and failure.
Birgit Gellersen,Jan J. Brosens +1 more
TL;DR: The endocrine, paracrine, and autocrine cues that tightly govern this differentiation process are reviewed and how disorders that subvert the programming, initiation, or progression of decidualization compromise reproductive health and predispose for pregnancy failure is discussed.
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Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium
Margherita Y. Turco,Lucy Gardner,Jasmine Hughes,Tereza Cindrova-Davies,Maria J Gomez,Lydia Farrell,Michael Hollinshead,Steven G.E. Marsh,Jan J. Brosens,Hilary O. D. Critchley,Benjamin D. Simons,Myriam Hemberger,Myriam Hemberger,Bon-Kyoung Koo,Ashley Moffett,Graham J. Burton +15 more
TL;DR: These organoids expand long-term, are genetically stable and differentiate following treatment with reproductive hormones, and provide a foundation to study common diseases, such as endometriosis and endometrial cancer, as well as the physiology of early gestation.
Journal ArticleDOI
Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium
Paul J. Brighton,Yojiro Maruyama,Yojiro Maruyama,Katherine J. Fishwick,Pavle Vrljicak,Pavle Vrljicak,Shreeya Tewary,Shreeya Tewary,Risa Fujihara,Risa Fujihara,Joanne Muter,Emma S. Lucas,Emma S. Lucas,Taihei Yamada,Laura Woods,Laura Woods,Raffaella Lucciola,Yie Hou Lee,Yie Hou Lee,Satoru Takeda,Sascha Ott,Myriam Hemberger,Myriam Hemberger,Siobhan Quenby,Jan J. Brosens +24 more
TL;DR: The findings reveal that acute decidual senescence governs endometrial rejuvenation and remodeling at embryo implantation, and suggest a critical role for uNK cells in maintaining homeostasis in cycling endometrium.
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Embryo–epithelium interactions during implantation at a glance
John D. Aplin,Peter T Ruane +1 more
TL;DR: Evidence is emerging for a repertoire of transcription factors downstream of the master steroidal regulators estrogen and progesterone that coordinate alterations in epithelial polarity, delivery of signals to the stroma and epithelial cell death or displacement in rodent and human.
Journal ArticleDOI
Physical and neurobehavioral determinants of reproductive onset and success
Felix R. Day,Hannes Helgason,Hannes Helgason,Daniel I. Chasman,Daniel I. Chasman,Lynda M. Rose,Po-Ru Loh,Po-Ru Loh,Robert A. Scott,Agnar Helgason,Agnar Helgason,Augustine Kong,Augustine Kong,Gisli Masson,Olafur Th Magnusson,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Julie E. Buring,Julie E. Buring,Paul M. Ridker,Paul M. Ridker,Patrick Sulem,Kari Stefansson,Kari Stefansson,Ken K. Ong,John R. B. Perry +27 more
TL;DR: The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively and Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier firstSexual intercourse, earlier first birth and lower educational attainment.
References
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