Journal ArticleDOI
Rodent, large animal and non-human primate models of spinal cord injury
Raffaele Nardone,Cristina Florea,Yvonne Höller,Francesco Brigo,Viviana Versace,Piergiorgio Lochner,Stefan Golaszewski,Eugen Trinka +7 more
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TLDR
The different experimental models of SCI have advantages and disadvantages for investigating the different aspects of lesion development, recovery mechanisms and potential therapeutic interventions and the translation from experimental repair strategies to clinical applications needs to be investigated.About:
This article is published in Zoology.The article was published on 2017-08-01. It has received 49 citations till now.read more
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Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms.
TL;DR: The neurological outcomes of human SCI and the available experimental model systems that have been employed to identify SCI mechanisms and develop therapeutic strategies for this condition are discussed.
Journal ArticleDOI
Novel multi-drug delivery hydrogel using scar-homing liposomes improves spinal cord injury repair.
Qingqing Wang,Hongyu Zhang,He-Lin Xu,Ying-Zheng Zhao,Zhengmao Li,Jiawei Li,Haoli Wang,De-Li ZhuGe,Xin Guo,Huazi Xu,Salazar Jones,Xiaokun Li,Xiaofeng Jia,Xiaofeng Jia,Jian Xiao +14 more
TL;DR: A novel multifunctional therapeutic strategy with a scar-homing delivery system that supported neuro-regeneration by improving neuronal survival and plasticity and promoted axonal regeneration via moderation of microtubule function and mitochondrial transport along the regenerating axon.
Journal ArticleDOI
Recovery of paralyzed limb motor function in canine with complete spinal cord injury following implantation of MSC-derived neural network tissue.
Guo-Hui Wu,Hui-juan Shi,Ming-Tian Che,Meng-Yao Huang,Qing-Shuai Wei,Bo Feng,Yuan-Huan Ma,Lai-Jian Wang,Bin Jiang,Ya-Qiong Wang,Inbo Han,Eng-Ang Ling,Xiang Zeng,Yuan-Shan Zeng +13 more
TL;DR: The results suggest that the transplanted MSC-derived neural network tissue may serve as a structural and functional "neuronal relay" to restore the paralyzed limb motor function in the canine with complete SCI.
Journal Article
Spinal cord injury models.
TL;DR: Rat models of injury with injury produced by impact, compression, or even photochemical techniques are relied on and a new approach to therapy is being explored via implantation of cells into the injured spinal cord via cell suspensions.
Journal ArticleDOI
Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering.
TL;DR: The technologies related to ex vivo models and lab-on-a-chip devices for studying the regeneration of brain, spinal cord, and peripheral nerve tissues are essential tools for neural tissue engineering and regenerative medicine research.
References
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The principles of humane experimental technique
W. M. S. Russell,R. L. Burch +1 more
TL;DR: The Principles of Humane Experimental Technique as mentioned in this paper, by W. M. S. Russell and R. L. Burch, 1959, London: Methuen & Co. Limited.
Journal ArticleDOI
A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats
TL;DR: The data indicate that the BBB scale is a valid and predictive measure of locomotor recovery able to distinguish behavioral outcomes due to different injuries and to predict anatomical alterations at the lesion center.
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Chondroitinase ABC promotes functional recovery after spinal cord injury
Elizabeth J. Bradbury,Lawrence D. F. Moon,Lawrence D. F. Moon,Reena J Popat,V.R. King,GS Bennett,Preena N. Patel,James W. Fawcett,Stephen B. McMahon +8 more
TL;DR: It is demonstrated that CSPGs are important inhibitory molecules in vivo and suggested that their manipulation will be useful for treatment of human spinal injuries.
Journal ArticleDOI
Can Animal Models of Disease Reliably Inform Human Studies
H. Bart van der Worp,David W. Howells,Emily S. Sena,Emily S. Sena,Michelle J. Porritt,Sarah S J Rewell,Victoria E O'Collins,Malcolm R. Macleod +7 more
TL;DR: H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials and the prospects of doing so in the coming years.
Journal ArticleDOI
The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats.
Florence M. Bareyre,Florence M. Bareyre,Martin Kerschensteiner,Martin Kerschensteiner,Olivier Raineteau,Thomas C. Mettenleiter,Oliver Weinmann,Martin E. Schwab +7 more
TL;DR: The anatomical basis of this recovery was investigated and it was found that after incomplete spinal cord injury in rats, transected hindlimb corticospinal tract axons sprouted into the cervical gray matter to contact short and long propriospinal neurons (PSNs).