Journal ArticleDOI
Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responses.
TLDR
Results suggest central CRF and Ucn play a role in generating anxiety which may be similar to that seen in pathological conditions such as panic disorder.About:
This article is published in Behavioural Brain Research.The article was published on 1999-04-01. It has received 188 citations till now. The article focuses on the topics: Urocortin & Basolateral amygdala.read more
Citations
More filters
Journal ArticleDOI
The amygdala: vigilance and emotion
Michael Davis,Paul J. Whalen +1 more
TL;DR: A review of available studies examining the human amygdala covers both lesion and electrical stimulation studies as well as the most recent functional neuroimaging studies, and attempts to integrate basic information on normal amygdala function with the current understanding of psychiatric disorders, including pathological anxiety.
Journal ArticleDOI
Psychobiological Mechanisms of Resilience and Vulnerability: Implications for Successful Adaptation to Extreme Stress
TL;DR: An integrative model of resilience and vulnerability that encompasses the neurochemical response patterns to acute stress and the neural mechanisms mediating reward, fear conditioning and extinction, and social behavior is proposed.
Journal ArticleDOI
The neurobiology and control of anxious states
TL;DR: The present article focuses in particular upon the multifarious and complex roles of individual modulators, often as a function of the specific receptor type and neuronal substrate involved in their actions; novel targets for the management of anxiety disorders; the influence of neurotransmitters and other agents upon performance in the VCT; data acquired from complementary pharmacological and genetic strategies and, finally, several open questions likely to orientate future experimental- and clinical-research.
Journal ArticleDOI
A Role for Brain Stress Systems in Addiction
TL;DR: The role of brain stress systems and brain antistress systems in addiction provides novel targets for treatment and prevention of addiction and insights into the organization and function of basic brain emotional circuitry.
Journal ArticleDOI
Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
TL;DR: It is suggested that, although the bed nucleus of the stria terminalis may not be necessary for rapid-onset, short-duration behaviors which occur in response to specific threats, it may mediate slower-onsets, longer-lasting responses that frequently accompany sustained threats, and that may persist even after threat termination.
References
More filters
Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
TL;DR: A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like and β-endorphinlike immunoactivities by cultured anterior pituitary cells has been purified in this paper.
Journal ArticleDOI
Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions
TL;DR: It is proposed that stress-induced increases in glucocorticoid levels protect not against the source of stress itself but rather against the body's normal reactions to stress, preventing those reactions from overshooting and themselves threatening homeostasis.
Journal ArticleDOI
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
Joan Vaughan,Cynthia J. Donaldson,Jackson C. Bittencourt,Marilyn H. Perrin,Kathy A. Lewis,Steven W. Sutton,Raymond K. W. Chan,Andrew V. Turnbull,David A. Lovejoy,Catherine Rivier,Jean Rivier,Paul E. Sawchenko,Wylie Vale +12 more
TL;DR: This work characterized another mammalian member of the CRF family and localized its urotensin-like immunoreactivity to, and cloned related complementary DNAs from, a discrete rat midbrain region, and deduced a peptide that is related to u Rotensin and CRF, which is named urocortin, which could be an endogenous ligand for type-2 CRF receptors.
Journal ArticleDOI
Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?
Adrian J. Dunn,Craig W. Berridge +1 more
TL;DR: The cerebral distribution of CRF and binding sites for CRF is described in detail in the second part of this report, which aims to establish a baseline for the distribution of these sites in the brain.