Role of the cytokine-inducible SH2 protein CIS in desensitization of STAT5b signaling by continuous growth hormone
Prabha A. Ram,David J. Waxman +1 more
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TLDR
It is proposed that the cytokine signaling inhibitor CIS is a key mediator of the STAT5b desensitization response seen in cells and tissues exposed to GH chronically, such as adult female rat liver.About:
This article is published in Journal of Biological Chemistry.The article was published on 2000-12-15 and is currently open access. It has received 118 citations till now. The article focuses on the topics: Proteasome inhibitor & Growth hormone receptor.read more
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SOCS proteins: negative regulators of cytokine signaling.
TL;DR: Gene targeting has been used to generate mice lacking socs1, socs2, or socs3, in order to elucidate the physiological function of these SOCS family members, and it is revealed that SOCS1 plays a key role in the negative regulation of interferon‐γ signaling and in T cell differentiation.
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Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes
TL;DR: Key features of the cell signaling and molecular regulatory mechanisms by which sex-dependent plasma GH patterns impart sex specificity to the liver are discussed, which provide novel insights into the physiological regulation of both xenobiotic and endobiotic metabolism.
Journal ArticleDOI
IL-13 receptors and signaling pathways: An evolving web
TL;DR: The current understanding of the IL-13 receptors and signaling pathways is summarized, supported by many in vivo observations, including that administration ofIL-13 resulted in allergic inflammation, tissue-specific overexpression of IL- 13 in the lungs of transgenic mice resulted in airway inflammation and mucus hypersecretion.
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Estrogen regulation of growth hormone action
TL;DR: There is strong evidence that oral but not transdermal administration of estrogen impairs the metabolic action of GH in the liver, causing a fall in IGF-I production and fat oxidation and an impairment of GH effect in hypopituitary women on GH replacement.
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Growth Hormone Regulation of Sex-Dependent Liver Gene Expression
David J. Waxman,Caitlin O’Connor +1 more
TL;DR: The mechanisms whereby GH, via its sex-dependent temporal patterns of pituitary release, activates intracellular signaling leading to the sexually dimorphic transcription of CYPs and other liver-expressed genes are examined.
References
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STATs and Gene Regulation
TL;DR: The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.
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Proteasome inhibitors: valuable new tools for cell biologists.
Do Hee Lee,Alfred L. Goldberg +1 more
TL;DR: The actions of selective proteasome inhibitors are described, how they can be used to investigate cellular responses, the functions of the proteasomes demonstrated by such studies and their potential applications in the future.
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Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
Stephan Teglund,Catriona McKay,Erin G. Schuetz,Jan M. van Deursen,Dimitrios J. Stravopodis,Demin Wang,Michael Brown,Sara Bodner,Gerard Grosveld,James N. Ihle,James N. Ihle +10 more
TL;DR: The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin.
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Specific Inhibition of Stat3 Signal Transduction by PIAS3
TL;DR: Results indicate that PIAS3 is a specific inhibitor of Stat3, a signal transducer and activator of transcription-3 (Stat3) protein activated by the interleukin 6 family of cytokines, epidermal growth factor, and leptin.
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Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
Garry B. Udy,Raewyn P. Towers,Russell G. Snell,Richard J. Wilkins,Soo-Hee Park,Prabha A. Ram,David J. Waxman,Helen W. Davey +7 more
TL;DR: The requirement of STAT5b to maintain sexual dimorphism of body growth rates and liver gene expression suggests thatSTAT5b may be the major, if not the sole, STAT protein that mediates the sexually dimorphic effects of GH pulses in liver and perhaps other target tissues.
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