Journal ArticleDOI
Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer.
Evgenia Karousou,Suniti Misra,Shibnath Ghatak,Katalin Dobra,Martin Götte,Davide Vigetti,Alberto Passi,Nikos K. Karamanos,Spyros S. Skandalis +8 more
TLDR
This review highlights that the regulation of HA synthases (HASes) by post-translational modifications, such as O-GlcNAcylation and ubiquitination, environmental factors and the action of microRNAs is important for HA synthesis and secretion in the tumor microenvironment.About:
This article is published in Matrix Biology.The article was published on 2017-05-01. It has received 146 citations till now. The article focuses on the topics: Hyaluronan synthase & Cancer stem cell.read more
Citations
More filters
Journal ArticleDOI
The extracellular matrix as a multitasking player in disease.
TL;DR: Critical and emerging issues related to matrix assembly in tissues and the multitasking roles for ECM in diseases such as osteoarthritis, fibrosis, cancer, and genetic diseases are presented.
Journal ArticleDOI
The pathogenesis of endometriosis: Molecular and cell biology insights
Antonio Simone Laganà,Simone Garzon,Martin Götte,Paola Viganò,Massimo Franchi,Fabio Ghezzi,Dan C. Martin +6 more
TL;DR: A narrative review synthesizing the findings of the English literature retrieved from computerized databases from inception to June 2019 suggests that a single etiopathogenetic model is not sufficient to explain its complex pathobiology.
Journal ArticleDOI
Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.
Nikos K. Karamanos,Nikos K. Karamanos,Zoi Piperigkou,Zoi Piperigkou,Achilleas D. Theocharis,Hideto Watanabe,Marco Franchi,Stéphanie Baud,Stéphane Brézillon,Martin Götte,Alberto Passi,Davide Vigetti,Sylvie Ricard-Blum,Ralph D. Sanderson,Thomas Neill,Renato V. Iozzo +15 more
TL;DR: The primary goal of this comprehensive review is to summarize major achievements and paradigm-shifting discoveries made on the PG/GAG chemistry-biology axis, focusing on structural variability, structure-function relationships, metabolic, molecular, and epigenetic mechanisms underlying their synthesis.
Journal ArticleDOI
Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer.
Anastasia G. Tavianatou,Ilaria Caon,Marco Franchi,Zoi Piperigkou,Zoi Piperigkou,Devis Galesso,Nikos K. Karamanos,Nikos K. Karamanos +7 more
TL;DR: The primary goal of this review is to critically present the importance of HA molecular size on cellular signaling, functional cell properties, and morphology in normal and pathological conditions, including inflammation and cancer.
Journal ArticleDOI
A guide to the composition and functions of the extracellular matrix.
Nikos K. Karamanos,Achilleas D. Theocharis,Zoi Piperigkou,Dimitra Manou,Alberto Passi,Spyros S. Skandalis,Demitrios H. Vynios,Véronique Orian-Rousseau,Sylvie Ricard-Blum,Christian E.H. Schmelzer,Christian E.H. Schmelzer,Laurent Duca,Madeleine Durbee,Nikolaos A. Afratis,Linda Troeberg,Marco Franchi,Valentina Masola,Maurizio Onisto +17 more
TL;DR: Extracellular matrix (ECM) is a dynamic 3-dimensional network of macromolecules that provides structural support for the cells and tissues as discussed by the authors, and it plays key regulatory roles since it orchestrates cell signaling, functions, properties and morphology.
References
More filters
Journal ArticleDOI
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
TL;DR: Induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions is demonstrated and iPS cells, designated iPS, exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
CD44: From adhesion molecules to signalling regulators
TL;DR: Cell-adhesion molecules, once believed to function primarily in tethering cells to extracellular ligands, are now recognized as having broader functions in cellular signalling cascades and the CD44 transmembrane glycoprotein family adds new aspects to these roles by participating in signal-transduction processes.
Journal ArticleDOI
Hyaluronan: from extracellular glue to pericellular cue
TL;DR: This work highlights a key role for interactions between hyaluronan and tumour cells in several aspects of malignancy and indicates the possibility of new therapeutic strategies.
Journal ArticleDOI
A restricted cell population propagates glioblastoma growth after chemotherapy
Jian Chen,Yanjiao Li,Tzong-Shiue Yu,Tzong-Shiue Yu,Renée M. McKay,Dennis K. Burns,Steven G. Kernie,Luis F. Parada +7 more
TL;DR: A relatively quiescent subset of endogenous glioma cells, with properties similar to those proposed for cancer stem cells, is responsible for sustaining long-term tumour growth through the production of transient populations of highly proliferative cells.
Related Papers (5)
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Renato V. Iozzo,Liliana Schaefer +1 more