Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure
Scott D. Solomon,Muthiah Vaduganathan,Brian Claggett,Milton Packer,Milton Packer,Michael R. Zile,Michael R. Zile,Karl Swedberg,Karl Swedberg,Jean L. Rouleau,Marc A. Pfeffer,Akshay S. Desai,Lars Lund,Lars Køber,Inder S. Anand,Nancy K. Sweitzer,Gerard C.M. Linssen,Béla Merkely,Juan Luis Arango,Dragos Vinereanu,Chen Huan Chen,Michele Senni,Antonio S. Sibulo,Sergey Boytsov,Victor Shi,Adel R. Rizkala,Martin Lefkowitz,John J.V. McMurray +27 more
TLDR
The therapeutic effects of sacubitril/valsartan, compared with a renin-angiotensin-aldosterone–system inhibitor alone, vary by LVEF with treatment benefits, particularly for heart failure hospitalization, that appear to extend to patients with heart failure and mildly reduced ejection fraction.Abstract:
Background: While disease-modifying therapies exist for heart failure (HF) with reduced left ventricular ejection fraction (LVEF), few options are available for patients in the higher range of LVEF...read more
Citations
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Journal ArticleDOI
2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.
Theresa McDonagh,Marco Metra,Marianna Adamo,Roy S. Gardner,Andreas Baumbach,Michael Böhm,Haran Burri,Javed Butler,Jelena Čelutkienė,Ovidiu Chioncel,John G F Cleland,A J S Coats,Maria G Crespo-Leiro,Dimitrios Farmakis,Martine Gilard,Stephane Heymans,Arno W. Hoes,Tiny Jaarsma,Ewa A. Jankowska,Mitja Lainscak,Carolyn S.P. Lam,Alexander R. Lyon,John J.V. McMurray,Alexandre Mebazaa,Richard Mindham,Claudio Muneretto,Massimo F Piepoli,Susanna Price,Giuseppe M.C. Rosano,Frank Ruschitzka,Anne Kathrine Skibelund +30 more
Journal ArticleDOI
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Paul A. Heidenreich,Biykem Bozkurt,David Aguilar,Larry A. Allen,Joni J. Byun,Monica Colvin,Anita Deswal,Mark H. Drazner,Shannon M. Dunlay,Linda R. Evers,James C. Fang,Savitri Fedson,Gregg C. Fonarow,Salim S. Hayek,Adrian F. Hernandez,Prateeti Khazanie,Michelle M. Kittleson,Christopher S. Lee,Mark S. Link,Carmelo A. Milano,Lorraine C. Nnacheta,Alexander T. Sandhu,Lynne W. Stevenson,Orly Vardeny,Amanda R. Vest,Clyde W. Yancy +25 more
TL;DR: The "2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure" as discussed by the authors provides patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with heart failure.
Journal ArticleDOI
2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Theresa McDonagh,Marco Metra,Marianna Adamo,Roy S. Gardner,Andreas Baumbach,Michael Böhm,Haran Burri,Javed Butler,Jelena Čelutkienė,Ovidiu Chioncel,John G.F. Cleland,Andrew J.S. Coats,María G. Crespo-Leiro,Dimitrios Farmakis,Martine Gilard,Stephane Heymans,Arno W. Hoes,Tiny Jaarsma,Ewa A. Jankowska,Mitja Lainscak,Carolyn S.P. Lam,Alexander R. Lyon,John J.V. McMurray,Alexandre Mebazaa,R.H.S Mindham,Claudio Muneretto,Massimo Francesco Piepoli,Susanna Price,Giuseppe M.C. Rosano,Frank Ruschitzka,Anne Kathrine Skibelund +30 more
TL;DR: De Boer et al. as mentioned in this paper reviewed the work of as mentioned in this paper and found that the authors of the paper were concerned with the authorship of the document and not the content of the documents.
Journal ArticleDOI
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
TL;DR: The 2022 guideline as discussed by the authors provides patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with heart failure, with the intent to improve quality of care and align with patients' interests.
Journal ArticleDOI
Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association.
Biykem Bozkurt,Andrew J.S. Coats,Hiroyuki Tsutsui,Ca Magdy Abdelhamid,Stamatis Adamopoulos,Nancy M. Albert,Stefan D. Anker,John Atherton,Michael Böhm,Javed Butler,Mark H. Drazner,G. Michael Felker,Gerasimos Filippatos,Mona Fiuzat,Gregg C. Fonarow,Juan Esteban Gomez-Mesa,Paul A. Heidenreich,Teruhiko Imamura,Ewa A. Jankowska,James L. Januzzi,Prateeti Khazanie,Koichiro Kinugawa,Carolyn S.P. Lam,Yuya Matsue,Marco Metra,Tomohito Ohtani,Massimo F Piepoli,Piotr Ponikowski,Giuseppe M.C. Rosano,Yasushi Sakata,Petar M. Seferović,Randall C. Starling,John R. Teerlink,Orly Vardeny,Kazuhiro Yamamoto,Clyde W. Yancy,Jian Zhang,Shelley Zieroth +37 more
TL;DR: In this paper, a universal definition of heart failure (HF) was proposed, with symptoms and signs caused by structural and functional cardiac abnormality and corroborated by elevated natriuretic peptide levels and/or objective evidence of pulmonary or systemic congestion.
References
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Journal ArticleDOI
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Piotr Ponikowski,Adriaan A. Voors,Stefan D. Anker,Héctor Bueno,John G.F. Cleland,Andrew J.S. Coats,Volkmar Falk,José Ramón González-Juanatey,Veli-Pekka Harjola,Ewa A. Jankowska,Mariell Jessup,Cecilia Linde,Petros Nihoyannopoulos,John Parissis,Burkert Pieske,Jillian P. Riley,Giuseppe M.C. Rosano,Luis M. Ruilope,Frank Ruschitzka,Frans H. Rutten,Peter van der Meer +20 more
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Regression modeling strategies : with applications to linear models, logistic regression, and survival analysis
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Journal ArticleDOI
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Piotr Ponikowski,Adriaan A. Voors,Stefan D. Anker,Héctor Bueno,John G.F. Cleland,Andrew J.S. Coats,Volkmar Falk,José Ramón González-Juanatey,Veli-Pekka Harjola,Ewa A. Jankowska,Mariell Jessup,Cecilia Linde,Petros Nihoyannopoulos,John Parissis,Burkert Pieske,Jillian P. Riley,Giuseppe M.C. Rosano,Luis M. Ruilope,Frank Ruschitzka,Frans H. Rutten,Peter van der Meer +20 more
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John J.V. McMurray,Milton Packer,Akshay S. Desai,Jianjian Gong,Martin Lefkowitz,Adel R. Rizkala,Jean L. Rouleau,Victor Shi,Scott D. Solomon,Karl Swedberg,Michael R. Zile,Abstr Act +11 more
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Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis
TL;DR: The basic Bayesian framework must be constrained, use of the step function in computing the probability that a team would rank best or worst in a league, and implementation of a Dirichlet process prior are presented.
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2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
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