Journal ArticleDOI
Science-based bioprocess design for filamentous fungi
TLDR
This review summarizes current strategies for science-based bioprocess design and control for filamentous fungi aiming at reducing development times and increasing process economics and discusses recent developments and trends regarding three crucial aspects throughout the biop rocess life cycle of filamentous fungus.About:
This article is published in Trends in Biotechnology.The article was published on 2013-01-01. It has received 76 citations till now. The article focuses on the topics: Bioprocess.read more
Citations
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Journal ArticleDOI
Biotechnological potential of plant-associated endophytic fungi: hope versus hype.
TL;DR: The current challenges in transforming curiosity driven discoveries into industrial scale endophyte biotechnology are defined and the possible practical, feasible, and sustainable strategies that can lead to harnessing fungal endophytes-mediated pharmaceutical products are discussed.
Journal ArticleDOI
Challenges in industrial fermentation technology research.
Luca Riccardo Formenti,Anders Nørregaard,Andrijana Bolic,Daniela Alejandra Quintanilla Hernandez,Timo Hagemann,Timo Hagemann,Anna-Lena Heins,Hilde Kristina Larsson,Lisa Mears,Miguel Mauricio-Iglesias,Ulrich Krühne,Krist V. Gernaey +11 more
TL;DR: Computational fluid dynamics (CFD) is introduced as a promising tool that can be used to support the scaling up and scaling down of bioreactors, and for studying mixing and the potential occurrence of gradients in a tank.
Journal ArticleDOI
Antiviral Agents From Fungi: Diversity, Mechanisms and Potential Applications.
Riikka Linnakoski,Dhanik Reshamwala,Pyry Veteli,Marta Cortina-Escribano,Henri Vanhanen,Varpu Marjomäki +5 more
TL;DR: The current knowledge of fungi as producers of antiviral compounds is summarized and how the antiviral action has been assessed and what is known about the molecular mechanisms and actual targets are investigated.
Journal ArticleDOI
From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics.
TL;DR: This review summarises the current state in biotechnological production of marine fungal antibiotics and points out the enormous potential of biotechnology in all stages of the discovery-to-development pipeline.
Journal ArticleDOI
Biofuel production: an odyssey from metabolic engineering to fermentation scale-up.
TL;DR: Fermentation engineers need to adopt new metabolic flux analysis tools that integrate kinetics, hydrodynamics, and 13C-proteomics, to reveal the dynamic physiologies of the microbial host under large bioreactor conditions.
References
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Journal ArticleDOI
Fungal morphology and metabolite production in submerged mycelial processes.
TL;DR: This review is focused on the factors influencing the fungal morphology and metabolite production in submerged culture and the development of any particular morphological form.
BookDOI
Process analytical technology : spectroscopic tools and implementation strategies for the chemical and pharmaceutical industries
TL;DR: In this paper, the authors describe the history and development of NIR in process analytical chemistry, and present the future trends in the field of process analytical chemical research, as well as future research directions in this field.
Journal ArticleDOI
Characterization and control of fungal morphology for improved production performance in biotechnology.
Rainer Krull,Thomas Wucherpfennig,Manely Eslahpazir Esfandabadi,Robert Walisko,Guido Melzer,Dietmar C. Hempel,Ingo Kampen,Arno Kwade,Christoph Wittmann +8 more
TL;DR: The resulting morphology has been shown to be influenced strongly by process parameters, including power input through stirring and aeration, mass transfer characteristics, pH value, osmolality and the presence of solid micro-particles.
Journal ArticleDOI
Soft sensors in bioprocessing: A status report and recommendations
Reiner Luttmann,Daniel G. Bracewell,Gesine Cornelissen,Krist V. Gernaey,Jarka Glassey,Volker C. Hass,Christian M. Kaiser,Christian Preusse,Gerald Striedner,Carl-Fredrik Mandenius +9 more
TL;DR: The panel was to provide an update on the present status of the subject and to identify critical needs and issues for the furthering of the successful development of soft sensor methods in bioprocess engineering research and for industrial applications, in particular with focus on biopharmaceutical applications.
Journal ArticleDOI
Biomass measurement online: the performance of in situ measurements and software sensors
TL;DR: This review concentrates on the applications of dielectric spectroscopy, optical density, infrared spectroscopic, and fluorescence for in situ measurement of biomass.