Journal ArticleDOI
SEER update of incidence and trends in pediatric malignancies: acute lymphoblastic leukemia.
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TLDR
The overall incidence of ALL was 26/106 person-years between 1973 and 1998, but increased from 19/106person-years in 1973-77 to 28/107 person-year in 1993-98 (P < 0.0001) and 5-year survival was poorest among black males as mentioned in this paper.Abstract:
Background
Acute lymphoblastic leukemia (ALL) represents the most common malignancy of childhood. Its incidence peaks in children just before school entry age; i.e., in 2–3 year olds. It is known to be more common in white children in the USA; the incidence is also higher in boys than girls.
Procedure
We reviewed the 5,379 cases of ALL among persons under 20 years of age in the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) database.
Results
The overall incidence of ALL was 26/106 person-years between 1973 and 1998, but increased from 19/106 person-years in 1973–77 to 28/106 person-years in 1993–98 (P < 0.0001). Rates were 44% higher among Whites compared to Blacks (27/106 person-years vs. 15/106 person-years, P < 0.0001). In 1992–1998, the incidence rate for Hispanics was 43/106 person-years, significantly higher than non-Hispanics (28/106, P < 0.0001). White children with ALL had better 5-year survival rates than Black children with ALL (71% vs. 58%, P < 0.0001), and 5-year survival was poorest among black males.
Conclusions
ALL incidence has increased over the examined 25-year period. The rate in US whites is higher than that of US Blacks, and the rates in the Hispanic subgroup are the highest of all. While the median survival period is now more than 10 years overall, the 5-year survival rate remains poor for Black males under 4 years of age. Socioeconomic factors do not account for this difference, which may relate to ALL subtype distribution. Med Pediatr Oncol 2002;39:554–557. © 2002 Wiley-Liss, Inc.read more
Citations
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Journal ArticleDOI
Annual report to the nation on the status of cancer, 1975-2003, featuring cancer among U.S. Hispanic/Latino populations.
Holly L. Howe,Xiao-Cheng Wu,Xiao-Cheng Wu,Lynn A. G. Ries,Vilma Cokkinides,Faruque Ahmed,Ahmedin Jemal,Barry A. Miller,Melanie Williams,Melanie Williams,Elizabeth Ward,Phyllis A. Wingo,Amelie G. Ramirez,Brenda K. Edwards +13 more
TL;DR: The American Cancer Society, Centers for Disease Control and Prevention, National Cancer Institute, and North American Association of Central Cancer Registries collaborate annually to provide U.s. cancer information, this year featuring the first comprehensive compilation of cancer information for U.S. Latinos.
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Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005
TL;DR: The authors of this report evaluated incidence and survival trends by RMS demographic subgroups to inform future etiologic hypotheses.
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Childhood cancer epidemiology in low-income countries.
Scott C. Howard,Scott C. Howard,Monika L. Metzger,Monika L. Metzger,Judith A. Wilimas,Judith A. Wilimas,Yuri Quintana,Ching-Hon Pui,Ching-Hon Pui,Leslie L. Robison,Raul C. Ribeiro,Raul C. Ribeiro +11 more
TL;DR: Hospital‐based registries are both feasible and essential in LIC, and can be developed using available training programs for data managers and the free online Pediatric Oncology Networked Data Base (POND4kids.org), which allows collection, analysis, and sharing of data.
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An infectious aetiology for childhood acute leukaemia: a review of the evidence
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Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia.
Sima Jeha,Varsha Gandhi,Ka Wah Chan,Lisa McDonald,Irma Ramirez,Renee Madden,Michael Rytting,Mark Brandt,Michael J. Keating,William Plunkett,Hagop M. Kantarjian +10 more
TL;DR: Clofarabine is well tolerated and shows significant antileukemic activity in heavily pretreated children and in pediatric patients with refractory and relapsed leukemia.
References
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Asymptotically Efficient Rank Invariant Test Procedures
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TL;DR: The purpose of this report is to provide histology‐specific incidence rates within single‐year age groups, stratified by sex and race, among children.
Journal ArticleDOI
Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia.
TL;DR: Among all of the chromosomal abnormalities identified in childhood ALL, hyperdiploidy greater than 50 has been associated with the most favorable prognosis and the treatment outcome for patients with classical Ph+ or hypodiploid ALL is very poor even in programs of intensive chemotherapy; alternative treatment should be considered for such patients.
Journal ArticleDOI
Characterization of childhood acute leukemia with multiple myeloid and lymphoid markers at diagnosis and at relapse [see comments]
C H Pui,Susana C. Raimondi,Michael J. Schell,Gaston K. Rivera,J. Mirro,William M. Crist,Frederick G. Behm +6 more
TL;DR: Acute mixed-lineage leukemia does not adequately describe the heterogeneity of the cases identified in this study and should be replaced by a set of more restrictive terms that indicate the unique biologic features of these leukemias.