M
Malcolm Taylor
Researcher at University of Manchester
Publications - 20
Citations - 1497
Malcolm Taylor is an academic researcher from University of Manchester. The author has contributed to research in topics: Childhood Acute Lymphoblastic Leukemia & Childhood leukemia. The author has an hindex of 13, co-authored 20 publications receiving 1399 citations.
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Journal ArticleDOI
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.
Elli Papaemmanuil,Fay J. Hosking,Jayaram Vijayakrishnan,Amy Price,Bianca Olver,Eammon Sheridan,Sally E. Kinsey,Tracy Lightfoot,Eve Roman,Julie Irving,James M. Allan,Ian Tomlinson,Malcolm Taylor,Mel Greaves,Richard S. Houlston +14 more
TL;DR: Data show that common low-penetrance susceptibility alleles contribute to the risk of developing childhood ALL and provide new insight into disease causation of this specific hematological cancer.
Journal ArticleDOI
Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk
Amy L. Sherborne,Fay J. Hosking,Rashmi B. Prasad,Rajesh Kumar,Rolf Koehler,Jayaram Vijayakrishnan,Elli Papaemmanuil,Claus R. Bartram,Martin Stanulla,Martin Schrappe,Andreas Gast,Sara E. Dobbins,Yussanne Ma,Eamonn Sheridan,Malcolm Taylor,Sally E. Kinsey,T Lightfoot,Eve Roman,Julie Irving,James M. Allan,Anthony V. Moorman,Christine J. Harrison,Ian Tomlinson,Sue Richards,Martin Zimmermann,Csaba Szalai,Ágnes F. Semsei,Dániel J. Erdélyi,Maja Krajinovic,Daniel Sinnett,Jasmine Healy,Anna Gonzalez Neira,Norihiko Kawamata,Seishi Ogawa,H. Phillip Koeffler,Kari Hemminki,Mel Greaves,Richard S. Houlston +37 more
TL;DR: Common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 × 10−11), irrespective of cell lineage.
Journal ArticleDOI
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 ( REL ), 8q24.21 and 10p14 ( GATA3 )
Victor Enciso-Mora,Peter Broderick,Yussanne Ma,Ruth F. Jarrett,Henrik Hjalgrim,Kari Hemminki,Anke van den Berg,Bianca Olver,Amy Lloyd,Sara E. Dobbins,Tracy Lightfoot,Flora E. van Leeuwen,Asta Försti,Arjan Diepstra,Annegien Broeks,Jayaram Vijayakrishnan,Lesley Shield,Annette Lake,Dorothy Montgomery,Eve Roman,Andreas Engert,Elke Pogge von Strandmann,Katrin S. Reiners,Ilja M. Nolte,Karin E. Smedby,Hans-Olov Adami,Hans-Olov Adami,Nicola S. Russell,Bengt Glimelius,Bengt Glimelius,Stephen Hamilton-Dutoit,Marieke L. De Bruin,Lars P. Ryder,Daniel Molin,Karina Meden Sørensen,Ellen T. Chang,Ellen T. Chang,Malcolm Taylor,Rosie Cooke,Robert M.W. Hofstra,Helga Westers,Tom van Wezel,Ronald van Eijk,Alan Ashworth,Klaus Rostgaard,Mads Melbye,Anthony J. Swerdlow,Richard S. Houlston +47 more
TL;DR: The role of the major histocompatibility complex in disease etiology is confirmed by revealing a strong human leukocyte antigen (HLA) association and new insight is provided into the pathogenesis of cHL.
Journal ArticleDOI
Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups
Kevin Y. Urayama,Ruth F. Jarrett,Henrik Hjalgrim,Arjan Diepstra,Yoichiro Kamatani,Amelie Chabrier,Valerie Gaborieau,Anne Boland,Alexandra Nieters,Nikolaus Becker,Lenka Foretova,Yolanda Benavente,Marc Maynadié,Anthony Staines,Lesley Shield,Annette Lake,Dorothy Montgomery,Malcolm Taylor,Karin E. Smedby,Rose-Marie Amini,Hans-Olov Adami,Hans-Olov Adami,Bengt Glimelius,Bjarke Feenstra,Ilja M. Nolte,Lydia Visser,Gustaaf W. van Imhoff,Tracy Lightfoot,Pierluigi Cocco,Lambertus A. Kiemeney,Sita H. Vermeulen,Ivana Holcatova,Lars J. Vatten,Gary J. Macfarlane,Peter Thomson,David I. Conway,Simone Benhamou,Antonio Agudo,Claire M. Healy,Kim Overvad,Anne Tjønneland,Beatrice Melin,Federico Canzian,Kay-Tee Khaw,Ruth C. Travis,Petra H.M. Peeters,Carlos González,José Ramón Quirós,María José Sánchez,José María Huerta,Eva Ardanaz,M. Dorronsoro,Françoise Clavel-Chapelon,H. Bas Bueno-de-Mesquita,Elio Riboli,Eve Roman,Paolo Boffetta,Silvia de Sanjosé,Diana Zelenika,Mads Melbye,Anke van den Berg,Mark Lathrop,Paul Brennan,James McKay +63 more
TL;DR: There is strong evidence that EBV status is an etiologically important classification of cHL and also suggest that some components of the pathological process are common to both EBV-positive andEBV-negative patients.
Journal ArticleDOI
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood
Rashmi B. Prasad,Fay J. Hosking,Jayaram Vijayakrishnan,Elli Papaemmanuil,Rolf Koehler,Mel Greaves,Eamonn Sheridan,Andreas Gast,Sally E. Kinsey,Tracy Lightfoot,Eve Roman,Malcolm Taylor,Kathy Pritchard-Jones,Martin Stanulla,Martin Schrappe,Claus R. Bartram,Richard S. Houlston,Rajesh Kumar,Kari Hemminki +18 more
TL;DR: The data provide unambiguous evidence for the role of these variants in defining ALL risk underscoring approximately 64% of cases, consistent with a polygenic model of disease susceptibility.