Journal ArticleDOI
Selectinminus signCarbohydrate Interactions: From Natural Ligands to Designed Mimics.
Reads0
Chats0
TLDR
9. Dimers of Miyauchi 853 10. BSA Glycoconjugates of Jacob 853 11. Polymeric Fucopeptides of Wong 853 IV.Abstract:
9. Dimers of Miyauchi 853 10. BSA Glycoconjugates of Jacob 853 11. Polymeric Fucopeptides of Wong 853 IV. Inhibitors Not Based upon Sialyl Lewisx 854 A. Polyanions 854 B. Peptides 855 C. Natural Products 855 1. Glycorrhyzin-Type Molecules 855 2. Deoxynojirimycin-Containing SLex 856 V. Evaluation of Target Structures 856 A. Cytel Assay 856 B. Novartis Assay 857 C. Glycolipid Assay of Lasky, Hasegawa, and Brandley 857read more
Citations
More filters
Journal ArticleDOI
Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
TL;DR: This review will focus on the nature of the polymers involved in the preparation of targeted nanocarriers, the synthesis methods to achieve the desired macromolecular architecture, the selected coupling strategy, and the choice of the homing molecules (vitamins, hormones, peptides, proteins, etc.), as well as the various strategies to display them at the surface of nanoccarriers.
Journal ArticleDOI
Multivalency as a chemical organization and action principle.
Carlo Fasting,Christoph A. Schalley,Marcus Weber,Oliver Seitz,Stefan Hecht,Beate Koksch,Jens Dernedde,Christina Graf,Ernst-Walter Knapp,Rainer Haag +9 more
TL;DR: In a systematic review of scaffold architectures, the underlying effects and control options will be demonstrated, and suggestions will be given for designing effective multivalent binding systems, as well as for polyvalent therapeutics.
Journal ArticleDOI
Synthetic Multivalent Ligands as Probes of Signal Transduction
TL;DR: This Review focuses on the use of synthetic multivalent ligands to characterize receptor function through chemical synthesis to address the role of receptor assembly in signal transduction.
Journal ArticleDOI
Glycoprotein synthesis: an update.
TL;DR: Glycoprotein Remodeling (GPR) 152, Enzymatic Formation of the Glycan-Protein/ Peptide Link 153, and enzymatics in Glycan Extension 4.2.1.
Journal ArticleDOI
Synthetic multivalent ligands in the exploration of cell-surface interactions.
TL;DR: Synthetic multivalent ligands provide insight into how cells exploit multivalent interactions to bind with increased avidity and specificity and how cell-surface receptor organization influences signaling and the cellular responses that result.
References
More filters
Journal ArticleDOI
Integrins: versatility, modulation, and signaling in cell adhesion.
Journal ArticleDOI
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Journal ArticleDOI
Adhesion receptors of the immune system.
TL;DR: Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responses.
Journal ArticleDOI
Biological roles of oligosaccharides: all of the theories are correct
TL;DR: The only common features of the varied functions of oligosaccharides are that they either mediate ‘specific recognition’ events or that they provide ‘modulation’ of biological processes.
Journal ArticleDOI
Integrins and signal transduction pathways: the road taken
Edwin A. Clark,Joan S. Brugge +1 more
TL;DR: Recent advances in understanding of intracellular signal transduction pathways regulated by the integrin family of adhesion receptors are focused on.