Journal ArticleDOI
Selective inhibition of the anchorage-independent growth of myc-transfected fibroblasts by retinoic acid.
TLDR
It is shown that induction of anchorage-independent growth by each of these sets of growth factors involves different cellular pathways which can be distinguished by their sensitivity to retinoic acid.Abstract:
Selective inhibition of the anchorage-independent growth of myc-transfected fibroblasts by retinoic acidread more
Citations
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Transforming growth factor-beta: biological function and chemical structure
TL;DR: TGF-beta's marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications.
Journal ArticleDOI
Transforming Growth Factor-β
TL;DR: Transforming growth factor-β (TGF-β) as mentioned in this paper is the cytokine with the broadest range of activities in repair of injured tissue, based both on the variety of cell types that produce and/or respond to it and on the spectrum of its cellular responses.
Journal ArticleDOI
Distribution and modulation of the cellular receptor for transforming growth factor-beta.
TL;DR: The biologically inactive form of TGF-beta, which constitutes greater than 98% of autocrine T GF-beta secreted by all of the twelve different cell types assayed, was shown to be unable to bind to the receptor without prior activation in vitro, and it is proposed that this may prevent premature interaction of Autocrine ligand and receptor in the Golgi apparatus.
Journal ArticleDOI
Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis.
Kenneth K. Tanabe,Antoinette Lemoine,Dianne M. Finkelstein,Hiroshi Kawasaki,Tsutomu Fujii,Raymond T. Chung,Gregory Y. Lauwers,Yakup Kulu,Alona Muzikansky,Darshini Kuruppu,Michael Lanuti,Jonathan M. Goodwin,Daniel Azoulay,Bryan C. Fuchs +13 more
TL;DR: The EGF gene polymorphism genotype is associated with risk for development of hepatocellular carcinoma in liver cirrhosis through modulation of EGF levels through inhibition fragment-length polymorphism.
Journal ArticleDOI
Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor.
TL;DR: A model for the mechanism of cooperation between myc and ras oncogenes is suggested in which ras- like genes induce growth factor production, while myc-like genes increase the responsiveness of cells to these factors.
References
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Journal ArticleDOI
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.
TL;DR: The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.
Journal ArticleDOI
Cell-Specific Regulation of the c-myc Gene by Lymphocyte Mitogens and Platelet-Derived Growth Factor
TL;DR: A regulatory linkage between the function of two oncogenes--c-myc and c-sis--the latter being the putative structural gene for PDGF is suggested, consistent with a model that a labile protein may regulate c- myc levels in these cells.
Journal ArticleDOI
Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.
TL;DR: The results show that platelets contain a type beta transforming growth factor, which is distinct from platelet-derived growth factor and elicits 50% of its maximal biological response at concentrations less than 5 x 10(-12) M.
Journal ArticleDOI
Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.
Michael D. Waterfield,Geoffrey T. Scrace,Nigel Whittle,Paul Stroobant,Ann Johnsson,Åke Wasteson,Bengt Westermark,Carl-Henrik Heldin,Jung San Huang,Thomas F. Deuel +9 more
TL;DR: A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, shows virtual identity with the predicted sequence of p28sis, the putative transforming protein of simian sarcoma virus (SSV).
Journal ArticleDOI
Type beta transforming growth factor: a bifunctional regulator of cellular growth.
Anita B. Roberts,Mario A. Anzano,Lalage M. Wakefield,Nanette S. Roche,David F. Stern,Michael B. Sporn +5 more
TL;DR: The data indicate that the effects of TGF-beta on cells are not a function of the peptide itself, but rather of the total set of growth factors and their receptors that is operant in the cell at a given time.