Journal ArticleDOI
Selenium and drug metabolism—I: Multiple modulations of mouse liver enzymes
Rudolf Reiter,Albrecht Wendel +1 more
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TLDR
The data indicate that in addition to GSH-Px many other enzyme activities in mouse liver are affected by prolonged dietary selenium deficiency, and might be useful in assessing the severity of seenium deficiency.About:
This article is published in Biochemical Pharmacology.The article was published on 1983-10-15. It has received 69 citations till now. The article focuses on the topics: Selenium deficiency & Glutathione peroxidase.read more
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Antioxidant activity of albumin-bound bilirubin.
TL;DR: Results show that 1 mol of Alb-BR can scavenge 2 mol of peroxyl radicals and that small amounts of plasma bilirubin are sufficient to prevent oxidation of albumin-bound fatty acids as well as of the protein itself, indicating a role for Alb- BR as a physiological antioxidant in plasma and the extravascular space.
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Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase
TL;DR: A novel chemopreventive mechanism is proposed involving Se catalysis of reversible cysteine/disulfide transformations that occur in a number of redox-regulated proteins, including transcription factors, which would allow normalization of critical cellular processes in the early stages of transformation.
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Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors
TL;DR: This article reviewed principles of redox regulation with special emphasis on chemical feasibility, kinetic requirements, specificity, and physiological context, taking well investigated mammalian transcription factor systems, nuclear transcription factor of bone marrow-derived lymphocytes (NF-κB), and kelch-like ECH-associated protein-1 (Keap1)/Nrf2, as paradigms.
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A novel biologically active seleno-organic compound--II. Activity of PZ 51 in relation to glutathione peroxidase.
TL;DR: In mouse liver microsomes, NADPH-dependent aminopyrine dealkylation was totally inhibited in the presence of 50 mumol/1 PZ 51, and in vivo experiments with Se-deficient mice showed that the Se-moiety of Pz 51 is not available for the synthesis of the selenoenzyme GSH-Px after dietary treatment or i.p. doses up to 25 mg Se.
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Lipid peroxidation and mechanisms of toxicity.
Alan A. Horton,Steven Fairhurst +1 more
TL;DR: The possibility exists that certain foreign compounds may interfere with or even overwhelm these defenses, and herein could lie a general mechanism of toxicity.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
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Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. 1951.
Klaus Schwarz,Calvin M. Foltz +1 more
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Microsomal Heme Oxygenase CHARACTERIZATION OF THE ENZYME
TL;DR: The kinetics and tissue distribution of the microsomal heme oxygenase suggest that it is of major importance in the physiological degradation of hemoglobin and other hemoproteins to bile pigment.
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Glutathione peroxidase: A selenoenzyme
TL;DR: The aulh,o~s described an incorpora t ion o f in t raper imne~ ly injee~ted '~s Se in to a IVrOtein f ract ion w N e h after partial puMfieafion showed GSH peroxidase a ctiVi:ty.