Self-report measures of antiretroviral therapy adherence: A review with recommendations for HIV research and clinical management.
Jane M. Simoni,Ann Kurth,Cynthia R. Pearson,David W. Pantalone,Joseph O. Merrill,Pamela A. Frick +5 more
TLDR
It is concluded that even brief self-report measures of antiretroviral adherence can be robust, and recommend items and strategies for HIV research and clinical management.Abstract:
A review of 77 studies employing self-report measures of antiretroviral adherence published 1/1996 through 8/2004 revealed great variety in adherence assessment item content, format, and response options. Recall periods ranged from 2 to 365 days (mode=7 days). The most common cutoff for optimal adherence was 100% (21/48 studies, or 44%). In 27 of 34 recall periods (79%), self-reported adherence was associated with adherence as assessed with other indirect measures. Data from 57 of 67 recall periods (84%) indicated self-reported adherence was significantly associated with HIV-1 RNA viral load; in 16 of 26 (62%), it was associated with CD4 count. Clearly, the field would benefit from item standardization and a priori definitions and operationalizations of adherence. We conclude that even brief self-report measures of antiretroviral adherence can be robust, and recommend items and strategies for HIV research and clinical management.read more
Citations
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British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008
Brian Gazzard,Jane Anderson,Abdel Babiker,Marta Boffito,Gary Brook,Gary Brough,Duncan Churchill,Ben Cromarty,Satyajit Das,Martin Fisher,Andrew L. Freedman,Anna Maria Geretti,Margaret A. Johnson,Saye Khoo,Clifford Leen,Devaki Nair,Barry Peters,Andrew N. Phillips,Deenan Pillay,Anton Pozniak,John P. Walsh,Ed Wilkins,Ian S. Williams,Matthew Williams,M Youle +24 more
TL;DR: The 2008 BHIVA Guidelines have been updated to incorporate all the new relevant information since the last iteration and all the peer-reviewed publications and important, potentially treatment-changing abstracts from the last 2 years have been reviewed.
Journal ArticleDOI
Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial
Richard T. Lester,Richard T. Lester,Richard T. Lester,Paul Ritvo,Edward J Mills,Antony Kariri,Sarah Karanja,Michael H. Chung,William Jack,James Habyarimana,Mohsen Sadatsafavi,Mehdi Najafzadeh,Carlo A. Marra,Benson B. Estambale,Elizabeth N. Ngugi,T. Blake Ball,Lehana Thabane,Lawrence Gelmon,Lawrence Gelmon,Joshua Kimani,Joshua Kimani,Marta Ackers,Francis A. Plummer,Francis A. Plummer +23 more
TL;DR: Patients who received SMS support had significantly improved ART adherence and rates of viral suppression compared with the control individuals, suggesting mobile phones might be effective tools to improve patient outcome in resource-limited settings.
Eff ects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial
R T Lester,Richard T. Lester,Paul Ritvo,Edward J. Mills,Antony Kariri,Sarah Karanja,Michael H. Chung,William Jack,James Habyarimana,Mohsen Sadatsafavi,Mehdi Najafzadeh,Carlo A. Marra,Benson B. Estambale,Elizabeth N. Ngugi,T. Blake Ball,Lehana Thabane,Lawrence Gelmon,Joshua Kimani,Marta Ackers,Francis A. Plummer +19 more
TL;DR: In this article, a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial is presented, which is based on a randomized trial.
Journal ArticleDOI
Self-report measures of medication adherence behavior: recommendations on optimal use
Michael J. Stirratt,Jacqueline Dunbar-Jacob,Heidi M. Crane,Jane M. Simoni,Susan M. Czajkowski,Marisa E. Hilliard,James E. Aikens,Christine M. Hunter,Dawn I. Velligan,Kristen Huntley,Gbenga Ogedegbe,Cynthia S. Rand,Eleanor Schron,Wendy Nilsen +13 more
TL;DR: Most evidence indicates that self-report medication adherence measures show moderate correspondence to other adherence measures and can significantly predict clinical outcomes, which is preferred when speed, efficiency, and low-cost measures are required, as the case in clinical care.
Journal ArticleDOI
Alcohol use and antiretroviral adherence: review and meta-analysis.
TL;DR: Results support a significant and reliable association of alcohol use and medication nonadherence and Methodological variables seem to moderate this association and could contribute to inconsistent findings across studies.
References
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Concurrent and predictive validity of a self reported measure of medication adherence
TL;DR: The psychometric properties and predictive validity of a structured four-item self-reported adherence measure (alpha reliability = 0.61) are tested, which can be easily integrated into the medical visit and address barriers to medication-taking.
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Adherence to protease inhibitor therapy and outcomes in patients with HIV infection.
David L. Paterson,Susan Swindells,J. Mohr,Michelle Brester,Emanuel N. Vergis,Cheryl Squier,Marilyn M. Wagener,Nina Singh +7 more
TL;DR: Given the critical importance of adherence to therapy to patient outcome, secondary prevention of HIV infection, and willingness of providers to prescribe therapy, this prospectively investigated the association between protease inhibitor adherence and patient outcome and factors related to adherence.
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Variations in patients' adherence to medical recommendations: A quantitative review of 50 years of research
TL;DR: This review offers insights into the literature on patient adherence, providing direction for future research, and focuses on reliability and validity of adherence measurement and systematic study of substantive and methodologic moderators.
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Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG Adherence Instruments
Margaret A. Chesney,Jeannette R. Ickovics,Donald B. Chambers,Allen L. Gifford,Judith L. Neidig,B. Zwickl,Albert W. Wu +6 more
TL;DR: The AACTG Adherence Instruments, which are comprised of two self-report questionnaires for use in clinical trials conducted by the Adult AIDS Clinical Trials Group (AACTG), were administered to 75 patients in the USA.