Journal ArticleDOI
Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection.
Adriana Ammassari,Rita Murri,Patrizio Pezzotti,Maria Paola Trotta,Laura Ravasio,Patrizio De Longis,Sergio Lo Caputo,Pasquale Narciso,S. Pauluzzi,Giampiero Carosi,Salvatore Nappa,P. Piano,Izzo Cm,Miriam Lichtner,Giovanni Rezza,Antonella d'Arminio Monforte,Giuseppe Ippolito,Mauro Moroni,Albert W. Wu,Andrea Antinori +19 more
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TLDR
In addition to patient characteristics, medication‐related variables, and reasons for nonadherence, patient‐reported symptoms and medication side effects were significantly associated with adherence to HAART.Abstract:
Objectives To identify variables predictive of nonadherence to highly active antiretroviral therapy (HAART) and to assess whether self-reported symptoms or medication side effects are related to adherence. Design Cross-sectional multicenter study Adherence Italian Cohort Naive Antiretrovirals [AdICONA] within the Italian Cohort Naive Antiretrovirals (ICONA). Methods Participants receiving HAART completed a 16-item self-administered questionnaire to assess nonadherence in the last 3 days as well as the type and intensity of 24 common HIV- and HAART-related symptoms experienced during the last 4 weeks. Results From May 1999 to March 2000, 358 persons were enrolled: 22% reported nonadherence and were less likely to have HIV RNA Conclusions In addition to patient characteristics, medication-related variables, and reasons for nonadherence, patient-reported symptoms and medication side effects were significantly associated with adherence to HAART.read more
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Adherence to HAART: A Systematic Review of Developed and Developing Nation Patient-Reported Barriers and Facilitators
Edward J Mills,Jean B. Nachega,David R. Bangsberg,Sonal Singh,Beth Rachlis,Ping-ping Wu,Kumanan Wilson,Iain Buchan,Christopher J. Gill,Curtis Cooper +9 more
TL;DR: Important barriers to adherence are consistent across multiple settings and countries, and Clinicians should use this information to engage in open discussion with patients to promote adherence and identify barriers and facilitators within their own populations.
Journal ArticleDOI
Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana.
Sheri D. Weiser,William R. Wolfe,William R. Wolfe,David R. Bangsberg,Ibou Thior,Peter B. Gilbert,Joseph Makhema,Poloko Kebaabetswe,Dianne Dickenson,Kgosidialwa Mompati,Max Essex,Richard Marlink +11 more
TL;DR: ARV adherence rates in Botswana were comparable with those seen in developed countries, as health care providers were often unable to identify which patients adhere to their ARV regimens.
Journal ArticleDOI
Correlates and predictors of adherence to highly active antiretroviral therapy: overview of published literature.
Adriana Ammassari,Maria Paola Trotta,Rita Murri,Francesco Castelli,Pasquale Narciso,Pasquale Noto,Jacopo Vecchiet,Antonella d'Arminio Monforte,Albert W. Wu,Andrea Antinori +9 more
TL;DR: This review summarizes the results of 20 studies investigating the issue of barriers to optimal highly active antiretroviral therapy (HAART) adherence and found inconsistent findings regarding the relationship of adherence.
Journal ArticleDOI
Mortality of patients lost to follow-up in antiretroviral treatment programmes in resource-limited settings: systematic review and meta-analysis
Martin W. G. Brinkhof,Mar Pujades-Rodriguez,Mar Pujades-Rodriguez,Matthias Egger,Matthias Egger +4 more
TL;DR: A substantial minority of adults lost to follow up cannot be traced, and among those traced 20% to 60% had died, which has implications both for patient care and the monitoring and evaluation of programmes.
Journal ArticleDOI
An objective case definition of lipodystrophy in HIV-infected adults: a case-control study
TL;DR: An objective, sensitive, specific, and broadly applicable case definition of HIV lipodystrophy is developed to improve assessment of lipodystrophic prevalence, risk factors, and pathogenesis; prevention and treatment approaches; and assist in diagnosis.
References
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Journal ArticleDOI
Adherence to protease inhibitor therapy and outcomes in patients with HIV infection.
David L. Paterson,Susan Swindells,J. Mohr,Michelle Brester,Emanuel N. Vergis,Cheryl Squier,Marilyn M. Wagener,Nina Singh +7 more
TL;DR: Given the critical importance of adherence to therapy to patient outcome, secondary prevention of HIV infection, and willingness of providers to prescribe therapy, this prospectively investigated the association between protease inhibitor adherence and patient outcome and factors related to adherence.
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Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population.
David R. Bangsberg,Frederick Hecht,Edwin D. Charlebois,Andrew R. Zolopa,Mark Holodniy,Mark Holodniy,Lewis B. Sheiner,Joshua D. Bamberger,Margaret A. Chesney,Andrew R. Moss +9 more
TL;DR: A substantial proportion of homeless and marginally housed individuals had good adherence to PI therapy and a strong relationship was found between independent methods of measuring adherence and concurrent viral suppression.
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Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions.
TL;DR: The hypothesis was that the virologic response to HAART would be substantially worse among unselected patients in an inner-city clinic than among patients enrolled in clinical trials, and this study analyzed data from a cohort of protease inhibitor-naive patients in whom HAART was initiated in the clinic between March 1996 and February 1998.
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Sociodemographic and psychological variables influencing adherence to antiretroviral therapy.
TL;DR: Overall, IVDUs and younger individuals tend to have a poorer compliance, as well as subjects with depression and lack of self-perceived social support, which should indirectly improve the effectiveness of antiretroviral therapy.
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A health status questionnaire using 30 items from the Medical Outcomes Study. Preliminary validation in persons with early HIV infection
Albert W. Wu,Haya R. Rubin,William C. Mathews,John E. Ware,Lucy T. Brysk,W D Hardy,Samuel A. Bozzette,Stephen A. Spector,Douglas D. Richman,Douglas D. Richman +9 more
TL;DR: A modified measure of human immunodeficiency virus-relevant items developed for the Medical Outcomes Study from subscales for cognitive function, energy/fatigue, health distress, and a single quality of life item were added to a portion of the MOS Short-form General Health Survey.