Semen quality among Danish and Finnish men attempting to conceive. The Danish First Pregnancy Planner Study Team
Tina Kold Jensen,Matti Vierula,Niels Henrik Hjollund,M. Saaranen,Thomas H. Scheike,S. Saarikoski,J. Suominen,A. Keiski,Jorma Toppari,N E Skakkebaek +9 more
TLDR
Comparison of semen quality between similar populations from Denmark and Finland found that median sperm concentration, total sperm count and the percentage of morphologically normal spermatozoa were significantly higher among the Finnish men without proven fertility than among Danish men.Abstract:
Objective To assess differences in semen quality between similar populations from Denmark and Finland. Design Comparison of semen quality between 221 Finnish men (of whom 115 had no proven fertility) and 411 Danish men with no proven fertility in two follow-up studies among normal couples trying to conceive. Methods In Finland male partners of couples without experienced infertility attempting to conceive were recruited through advertisements in local newspapers from 1984 to 1986. From 1992 to 1995 Danish men who lived with a partner and who had not attempted to achieve a pregnancy previously were recruited through their union when they discontinued birth control. All semen analyses were performed in accordance with the World Health Organization guidelines. Results Median sperm concentration, total sperm count and the percentage of morphologically normal spermatozoa were significantly higher among the Finnish men without proven fertility (104.0 million/ml, 304.0 million and 58% respectively) compared with the Danish men (53.0 million/ml, 140.8 million, and 41% respectively). Sperm concentration was 105.7% (95% confidence interval (CI) 58.1%-167.6%) and total sperm count was 127.4% (95% CI 71.4%-201.6%) higher among Finnish men without proven fertility than among Danish men after control for confounders. Conclusions Some, but hardly all, of the observed difference in semen quality may be explained by differences in recruitment procedures, selection of the men and by methodological differences in semen analysis between the two countries. Also a birth cohort effect may explain some of the differences between countries as the Finnish men were recruited 11 years before the Danish men. Therefore, follow-up studies with identical recruitment and selection of men from the two countries are needed.read more
Citations
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Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries.
Kirsten A Boisen,Marko Kaleva,Katharina M. Main,Helena E. Virtanen,A.M. Haavisto,A.M. Haavisto,Ida Maria Schmidt,Marla Chellakooty,Ida N. Damgaard,C Mau,Mikko S. Reunanen,Niels E. Skakkebæk,Jorma Toppari,Jorma Toppari +13 more
TL;DR: The findings of increasing and much higher prevalence of congenital cryptorchidism in Denmark than in Finland contribute evidence to the pattern of high frequency of reproductive problems such as testicular cancer and impaired semen quality in Danish men.
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Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects
TL;DR: Evidence supporting the hypothesis of developmental origin of testicular germ cell cancer is summarized, and epidemiological trends suggest a primary role for environmental factors, probably combined with genetic susceptibility.
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Phthalate exposure and human semen parameters.
Susan M. Duty,Manori J. Silva,Dana B. Barr,John W. Brock,Louise Ryan,Zuying Chen,Robert F. Herrick,David C. Christiani,Russ Hauser +8 more
TL;DR: There were dose-response relations for mono-butylphthalate and monobenzyl phthalate with one or more semen parameters, and suggestive evidence for monomethyl phhalate with sperm morphology, and the lack of a relation for other phthalates may indicate a difference in spermatotoxicity amongphthalates.
Journal ArticleDOI
Is smoking a risk factor for decreased semen quality? A cross-sectional analysis
Cecilia Høst Ramlau-Hansen,Ane Marie Thulstrup,Anette Skærbech Aggerholm,Morten Søndergaard Jensen,Gunnar Toft,Jens Peter Bonde +5 more
TL;DR: It would be sensible to advise men to abstain from smoking to avoid decreased fecundity, and a positive dose-response relationship between smoking and testosterone, LH and the LH/free testosterone ratios is found.
Journal ArticleDOI
Semen quality and reproductive health of young Czech men exposed to seasonal air pollution.
Sherry G. Selevan,Libor Borkovec,Valerie L. Slott,Zdena Zudova,Jiri Rubes,Donald P. Evenson,Sally D. Perreault +6 more
TL;DR: It is suggested that young men may experience alterations in sperm quality after exposure to periods of elevated air pollution, without changes in sperm numbers.
References
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Evidence for decreasing quality of semen during past 50 years.
TL;DR: There has been a genuine decline in semen quality over the past 50 years, and as male fertility is to some extent correlated with sperm count the results may reflect an overall reduction in male fertility.
Journal ArticleDOI
Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract
TL;DR: It is argued that the increasing incidence of reproductive abnormalities in the human male may be related to increased oestrogen exposure in utero, and mechanisms by which this exposure could occur are identified.
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Decline in Semen Quality among Fertile Men in Paris during the Past 20 Years
TL;DR: The volume of seminal fluid, the sperm concentration, and the percentages of motile and morphologically normal spermatozoa in 1351 healthy fertile men from 1973 through 1992 were measured.
Journal ArticleDOI
Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners
Jens Peter Bonde,Erik Ernst,Tina Kold Jensen,Niels Henrik Hjollund,Henrik A Kolstad,Thomas H. Scheike,Aleksander Giwercman,Niels E. Skakkebæk,Tine Brink Henriksen,Jørn Olsen +9 more
TL;DR: The study suggests that the current WHO guidelines for normal semen quality should be used with caution, as some men with sperm counts above the lower limit of the normal range defined by WHO may in fact be subfertile.
Journal ArticleDOI
Testicular cancer in nine northern european countries
Hans-Olov Adami,Hans-Olov Adami,Reinhold Bergström,Matthias Möhner,Witold Zatoôski,Hans H. Storm,Anders Ekbom,Steinar Tretli,Lyly Teppo,Hartwig Ziegler,Mati Rahu,Romualdas Gurevicius,Aivars Stengrevics +12 more
TL;DR: The data indicate that environmental influences on testicular cancer are strong, exposure to causal factors mostly takes place early in life, shows substantial geographical variation, and increases over time, so that the age‐standardized incidence doubles every 15 to 25 years.
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