Otto A. Meyer

TL;DR: The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active environmental chemicals during fetal and childhood development.

TL;DR: Implementation of a new toxicity testing paradigm firmly based on human biology by transitioning from current expensive and lengthy in vivo testing with qualitative endpoints to in vitro toxicity pathway assays on human cells or cell lines using robotic high-throughput screening with mechanistic quantitative parameters.

TL;DR: No single simple approach is available to judge upon potential interactions at the low doses that humans are exposed to from pesticide residues in food so PBTK models could be useful as tools to assess combined tissue doses and to help predict potential interactions including thresholds for such effects.

TL;DR: In this article, the degradation rate coefficient as a function of the temperature and the activation energy Ea is calculated using this Ea value, the ratio of degradation rates between two temperatures can be calculated.

TL;DR: Dose-related increases in the numbers of hepatocellular adenomas and carcinomas were statistically significant in male F1 rats when all groups together were tested for heterogeneity or analysis for trend, and the role of BHT in the development of hepatocytes requires further elucidation.