Journal ArticleDOI
Semicarbazide-sensitive amine oxidase in aortic smooth muscle cells mediates synthesis of a methylglyoxal-AGE: implications for vascular complications in diabetes.
TLDR
Immunostaining of tissue sections showed that aminoacetone-treated rats (normal as well as diabetic) formed more argpyrimidine in aortic smooth muscle than untreated controls, suggesting that SSAO can enhance AGE synthesis in the macrovasculature of diabetic individuals by production of MG.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2002-10-04. It has received 47 citations till now. The article focuses on the topics: Semicarbazide & Methylglyoxal.read more
Citations
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Journal ArticleDOI
Intervention against the Maillard reaction in vivo.
TL;DR: This Editorial sets the stage for a series of articles by experts in the field, who have made key contributions to the authors' understanding of the Maillard reaction in vivo.
Journal ArticleDOI
Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do.
TL;DR: SSAO, from some sources, behaves as a cellular adhesion protein under inflammatory and it may also be involved in lipid transport, and this review considers what is known about the activities and potential functions of this hardworking protein.
Journal ArticleDOI
The clinical relevance of advanced glycation endproducts (AGE) and recent developments in pharmaceutics to reduce AGE accumulation.
Andries Smit,HL Lutgers +1 more
TL;DR: The effects of receptor stimulation contribute to the development of chronic complications of conditions like diabetes mellitus, renal failure, and atherosclerosis and possible interventions to reduce the effects of AGE accumulation include AGE formation inhibitors or breakers, or receptor blockers, but possibly also dietary interventions.
Journal ArticleDOI
Vascular methylglyoxal metabolism and the development of hypertension
TL;DR: Investigation in spontaneously hypertensive rats found increased aortic MG, AGE formation and oxidative stress were associated with blood pressure increase in SHR, which may cause endothelial dysfunction and altered vascular reactivity.
Journal ArticleDOI
2-Aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis
TL;DR: 2-aminoadipic acid is a more reliable marker for protein oxidation than its precursor, allysine, and provides support for the presence of metal-catalysed oxidation (the Suyama pathway) in diabetes and the possible activation of myeloperoxidase during sepsis.
References
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superoxide production blocks three pathways of hyperglycaemic damage
Takeshi Nishikawa,Diane Edelstein,Xue Liang Du,Sho-ichi Yamagishi,Takeshi Matsumura,Yasufumi Kaneda,Mark A. Yorek,David Beebek,Peter J. Oatesk,Hans-Peter Hammes,Ida Giardino,Michael Brownlee +11 more
TL;DR: This paper showed that hyperglycaemia increases the production of reactive oxygen species inside cultured bovine aortic endothelial cells and that this increase in reactive oxygen can be prevented by an inhibitor of electron transport chain complex II, an uncoupler of oxidative phosphorylation, by uncoupling protein-1 and by manganese superoxide dismutase.
Journal ArticleDOI
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Takeshi Nishikawa,Diane Edelstein,Xue Liang Du,Sho-ichi Yamagishi,Takeshi Matsumura,Yasufumi Kaneda,Mark A. Yorek,David A. Beebe,Peter J. Oates,Hans-Peter Hammes,Ida Giardino,Michael Brownlee +11 more
TL;DR: This work shows that hyperglycaemia increases the production of reactive oxygen species inside cultured bovine aortic endothelial cells and is prevented by an inhibitor of electron transport chain complex II, by an uncoupler of oxidative phosphorylation, by uncoupling protein-1 and by manganese superoxide dismutase.
Journal ArticleDOI
Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions.
TL;DR: RAGE, an immunoglobulin superfamily member, mediates the binding of AGEs to endothelial cells and mononuclear phagocytes, interacts with a lactoferrin-like polypeptide that also binds A GEs, and appears to activate intracellular signal transduction mechanisms consequent to its interaction with the glycated ligand.
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N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins.
Mahtab U. Ahmed,Elisabeth Brinkmann Frye,Thorsten P. Degenhardt,Suzanne R. Thorpe,John W. Baynes +4 more
TL;DR: Levels of CML and CEL are proposed to provide an index of glyoxal and methylglyoxal concentrations in tissues, alterations in glutathione homoeostasis and dicarbonyl metabolism in disease, and sources of advanced glycation end-products in tissue proteins in aging and disease.
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Glycation and diabetic complications
TL;DR: A review of the mechanisms behind advanced glycation end products (AGEs) play a central role in the pathogenesis of diabetic complications and their effects on diabetic pathology concludes with a summary of AGE inhibition.