Journal ArticleDOI
Seminal fluid and fertility in women
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TLDR
Experiments in rodent models demonstrate a key role for seminal fluid in enabling robust embryo implantation and optimal placental development, and it will be important to define the mechanisms through which seminal fluid interacts with female reproductive tissues, to provide knowledge that may assist in preconception planning and infertility treatment.About:
This article is published in Fertility and Sterility.The article was published on 2016-09-01. It has received 146 citations till now. The article focuses on the topics: Infertility.read more
Citations
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Journal ArticleDOI
Regulatory T cells in embryo implantation and the immune response to pregnancy
TL;DR: The mechanisms acting in the conception environment to drive the Treg response are summarized and prospects for targeting the T cell compartment to alleviate immune-based reproductive disorders are discussed.
Journal ArticleDOI
Endometrial Decidualization: The Primary Driver of Pregnancy Health.
Shu-Wing Ng,Gabriella Norwitz,Mihaela Pavlicev,Tamara Tilburgs,Carlos Simón,Errol R. Norwitz,Errol R. Norwitz +6 more
TL;DR: It is hypothesize, therefore, that the primary driver of pregnancy health is the quality of the soil, not the seed.
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Immune Cells at the Fetomaternal Interface: How the Microenvironment Modulates Immune Cells To Foster Fetal Development.
TL;DR: This review article focuses on the local regulatory mechanisms ensuring that both innate and adaptive immune cells appropriately support the early events of implantation and placental development through direct involvement in promoting immune tolerance of fetal alloantigens, suppressing inflammation, and remodeling of maternal uterine vessels to facilitate optimal placental function and fetal growth.
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Identification and evaluation of the microbiome in the female and male reproductive tracts.
R. Koedooder,Shari Mackens,Andries E. Budding,Damiat Aoulad Fares,Christophe Blockeel,Joop S.E. Laven,Sam Schoenmakers +6 more
TL;DR: An overview of the currently used techniques and the reported microbiota compositions in the different anatomical parts of the female and male reproductive tracts since the introduction of NGS in 2005 is provided to understand and determine the interactions and roles of the different microbes necessary for successful reproduction.
Journal ArticleDOI
The Female Response to Seminal Fluid.
TL;DR: Male-female seminal fluid signaling is evident in all mammalian species investigated including human, and effects of seminal fluid in invertebrates indicate evolutionarily conserved mechanisms.
References
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Book
The biochemistry of semen and of the male reproductive tract.
TL;DR: Bromural, Its Distribution and Decomposition In the Animal Organism, and its Differential Diagnosis from Neurological Disorders, Acta Neurol.
Journal ArticleDOI
Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells
Felicita Baratelli,Ying Lin,Li Zhu,Seok-Chul Yang,Nathalie Heuzé-Vourc'h,Gang Zeng,Karen L. Reckamp,Mariam Dohadwala,Sherven Sharma,Steven M. Dubinett +9 more
TL;DR: PGE2 enhances the in vitro inhibitory function of human purified CD4+CD25+ T reg cells and induces a regulatory phenotype in CD4-CD25− T cells, the first report indicating that PGE2 can modulate FOXP3 expression and T reg function in human lymphocytes.
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Immunology of Pre-Eclampsia
TL;DR: In this paper, the pathogenesis of pre-eclampsia can be related to defined immune mechanisms that are appropriate to the fetomaternal frontier, and the first pregnancy preponderance and partner specificity can be explained by this model.
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Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization.
TL;DR: The results indicate that high frequency UC on the day of embryo transfer hinder IVF-embryo transfer outcome, possibly by expelling embryos out of the uterine cavity, and the negative correlation between UC frequency and progesterone concentrations supports the uterusine relaxing properties of progester one.
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Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions
Lucia Vojtech,Sangsoon Woo,Sean M. Hughes,Claire N. Levy,Lamar Ballweber,Renan Sauteraud,Johanna Strobl,Katharine Westerberg,Raphael Gottardo,Muneesh Tewari,Florian Hladik +10 more
TL;DR: It is found that seminal exosome (SE) preparations contain a substantial amount of RNA from 20 to 100 nucleotides (nts) in length, which could potentially deliver regulatory signals to the recipient mucosa via transfer of small RNA molecules.