Sensitivity of influenza rapid diagnostic tests to H5N1 and 2009 pandemic H1N1 viruses.
Yuko Sakai-Tagawa,Makoto Ozawa,Makoto Ozawa,Daisuke Tamura,Mai thi Quynh Le,Chairul A. Nidom,Norio Sugaya,Yoshihiro Kawaoka +7 more
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The results indicate that the detection sensitivity to swine origin H1N1 viruses varies widely among IRDTs, with some tests lacking sufficient sensitivity to detect the early stages of infection when the virus load is low.Abstract:
Simple and rapid diagnosis of influenza is useful for making treatment decisions in the clinical setting. Although many influenza rapid diagnostic tests (IRDTs) are available for the detection of seasonal influenza virus infections, their sensitivity for other viruses, such as H5N1 viruses and the recently emerged swine origin pandemic (H1N1) 2009 virus, remains largely unknown. Here, we examined the sensitivity of 20 IRDTs to various influenza virus strains, including H5N1 and 2009 pandemic H1N1 viruses. Our results indicate that the detection sensitivity to swine origin H1N1 viruses varies widely among IRDTs, with some tests lacking sufficient sensitivity to detect the early stages of infection when the virus load is low.read more
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Quantifying the causal impact of funding bedside antigen testing on the incidence of respiratory syncytial virus infection in Japan: a difference-in-differences study
TL;DR: Owing to financial support of bedside RSV antigen testing from 2012/13, the incidence of RSV infection has been elevated and should not be directly perceived as an increase in natural infections with RSV.
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Avian Influenza (H5N1) Update: Role of the Clinical Microbiology Laboratory
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Clinical Investigations. Comparison of Directigen Flu A+B with Real Time PCR in the Diagnosis of Influenza / Сравнение Иммунохроматографического Метода (Directigen Flu A+B) И Теста RT-PCR При Инфекциях Гриппа
Golubinka Bosevska,Nikola Panovski,Elizabeta Janceska,Vladimir Mikik,Irena Kondova Topuzovska,Zvonko Milenkovik +5 more
TL;DR: Directigen Flu A+B has relatively low sensitivity for detection of influenza viruses in combined nose and throat swabs, and negative results must be confirmed.
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Assesing sensitivity and specificity of rapid diagnostic test : the importance and challenges of Influenza surveillance in Indonesia
TL;DR: The results indicated that the SD Bioline rapid influenza test has a high specificity but has only low sensitivity for the detection of influenza from the throat and nasal swabs, Therefore, the integration of rapid test in the influenza surveillance needs further assessment to obtain optimal benefits for both clinical and public health sectors.
References
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Ron A. M. Fouchier,Peter M. Schneeberger,Frans W. Rozendaal,Jan M. Broekman,Stiena A. G. Kemink,Vincent J. Munster,Thijs Kuiken,Guus F. Rimmelzwaan,Martin Schutten,Gerard J. J. van Doornum,Guus Koch,A Bosman,Marion Koopmans,Albert D. M. E. Osterhaus +13 more
TL;DR: Because H7N7 viruses have caused disease in mammals, including horses, seals, and humans, on several occasions in the past, they may be unusual in their zoonotic potential and, thus, form a pandemic threat to humans.
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Neuraminidase Inhibitors for Influenza
TL;DR: The potential for the development of resistance especially limits the use of the adamantanes for the treatment of influenza, although the drugs still have a place in planning for prophylaxis during an epidemic.
Journal ArticleDOI
Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California.
Janice K. Louie,Meileen Acosta,Kathleen Winter,Cynthia Jean,Shilpa Gavali,Robert Schechter,Duc J. Vugia,Kathleen Harriman,Bela T. Matyas,Carol A. Glaser,Michael Samuel,Jon Rosenberg,John Talarico,Douglas L. Hatch +13 more
TL;DR: In the first 16 weeks of the current pandemic, the median age of hospitalized infected cases was younger than is common with seasonal influenza, and most cases had established risk factors for complications of seasonal influenza.
Journal ArticleDOI
Human infection with influenza H9N2
Malik Peiris,Kwok-Yung Yuen,C. W. Leung,Kwok-Hung Chan,P. L. S. Ip,Raymond Lai,W. K. Orr,Kennedy F. Shortridge +7 more
TL;DR: It is shown that serum samples from blood donors in Hong Kong had neutralising antibody suggestive of prior infection with influenza H9N2.