Journal ArticleDOI
Accuracy of rapid influenza diagnostic tests: a meta-analysis.
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TLDR
In this article, the authors examined the accuracy of rapid influenza diagnostic tests (RIDTs) in adults and children with influenza-like illness and evaluated factors associated with higher accuracy.Abstract:
Background Timely diagnosis of influenza can help clinical management. Purpose To examine the accuracy of rapid influenza diagnostic tests (RIDTs) in adults and children with influenza-like illness and evaluate factors associated with higher accuracy. Data sources PubMed and EMBASE through December 2011; BIOSIS and Web of Science through March 2010; and citations of articles, guidelines, reviews, and manufacturers. Study selection Studies that compared RIDTs with a reference standard of either reverse transcriptase polymerase chain reaction (first choice) or viral culture. Data extraction Reviewers abstracted study data by using a standardized form and assessed quality by using Quality Assessment of Diagnostic Accuracy Studies criteria. Data synthesis 159 studies evaluated 26 RIDTs, and 35% were conducted during the H1N1 pandemic. Failure to report whether results were assessed in a blinded manner and the basis for patient recruitment were important quality concerns. The pooled sensitivity and specificity were 62.3% (95% CI, 57.9% to 66.6%) and 98.2% (CI, 97.5% to 98.7%), respectively. The positive and negative likelihood ratios were 34.5 (CI, 23.8 to 45.2) and 0.38 (CI, 0.34 to 0.43), respectively. Sensitivity estimates were highly heterogeneous, which was partially explained by lower sensitivity in adults (53.9% [CI, 47.9% to 59.8%]) than in children (66.6% [CI, 61.6% to 71.7%]) and a higher sensitivity for influenza A (64.6% [CI, 59.0% to 70.1%) than for influenza B (52.2% [CI, 45.0% to 59.3%). Limitation Incomplete reporting limited the ability to assess the effect of important factors, such as specimen type and duration of influenza symptoms, on diagnostic accuracy. Conclusion Influenza can be ruled in but not ruled out through the use of RIDTs. Sensitivity varies across populations, but it is higher in children than in adults and for influenza A than for influenza B. Primary funding source Canadian Institutes of Health Research.read more
Citations
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Journal ArticleDOI
Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy.
Parinaz Fozouni,Sungmin Son,María Díaz de León Derby,Gavin J. Knott,Gavin J. Knott,Carley N. Gray,Carley N. Gray,Michael V. D’Ambrosio,Chunyu Zhao,Neil A. Switz,G. Renuka Kumar,G. Renuka Kumar,Stephanie I. Stephens,Stephanie I. Stephens,Daniela Boehm,Daniela Boehm,Chia-Lin Tsou,Chia-Lin Tsou,Jeffrey Shu,Jeffrey Shu,Abdul Bhuiya,Maxim Armstrong,Andrew R. Harris,Pei Yi Chen,Pei Yi Chen,Jeannette M. Osterloh,Anke Meyer-Franke,Bastian Joehnk,Keith Walcott,Anita Sil,Charles Langelier,Katherine S. Pollard,Emily D. Crawford,Andreas S. Puschnik,Maira Phelps,Amy Kistler,Joseph L. DeRisi,Jennifer A. Doudna,Daniel A. Fletcher,Melanie Ott +39 more
TL;DR: This work reports the development of an amplification-free CRISPR-Cas13a assay for direct detection of SARS-CoV-2 from nasal swab RNA that can be read with a mobile phone microscope and has the potential to enable rapid, low-cost, point-of-care screening for Sars-Cov-2.
Journal ArticleDOI
Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa
Timothy M. Uyeki,Henry H. Bernstein,John S. Bradley,John S. Bradley,Janet A. Englund,Thomas M. File,Alicia M. Fry,Stefan Gravenstein,Frederick G Hayden,Scott A. Harper,Jon Mark Hirshon,Michael G. Ison,B Lynn Johnston,Shandra L Knight,Allison McGeer,Laura E. Riley,Cameron R. Wolfe,Paul E. Alexander,Paul E. Alexander,Andrew T. Pavia +19 more
TL;DR: These clinical practice guidelines are an update of the guidelines published by the Infectious Diseases Society of America in 2009 and address new information regarding diagnostic testing, treatment and chemoprophylaxis with antiviral medications, and issues related to institutional outbreak management for seasonal influenza.
Journal ArticleDOI
Point-of-care testing for infectious diseases: diversity, complexity, and barriers in low- and middle-income countries.
Nitika Pant Pai,Caroline Vadnais,Claudia M. Denkinger,Claudia M. Denkinger,Nora Engel,Madhukar Pai,Madhukar Pai +6 more
TL;DR: A framework for envisioning how point-of-care testing can be applied to infectious diseases in low- and middle-income countries is discussed.
Journal ArticleDOI
Community-acquired pneumonia.
Daniel M. Musher,Anna R. Thorner +1 more
TL;DR: In this paper, community-acquired pneumonia is a commonly diagnosed illness in which no causative organism is identified in half the cases and molecular diagnostic techniques have the potential to lead to more targeted therapy in the face of increasing antibiotic resistance.
Journal ArticleDOI
A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology
J. Michael Miller,Matthew J. Binnicker,Sheldon Campbell,Karen C. Carroll,Kimberle C. Chapin,Peter H. Gilligan,Mark D. Gonzalez,Robert C. Jerris,Sue C. Kehl,Robin Patel,Bobbi S. Pritt,Sandra S. Richter,Barbara Robinson-Dunn,Joseph D. Schwartzman,James W. Snyder,Sam R. Telford,Elitza S. Theel,Richard B. Thomson,Melvin P. Weinstein,Joseph D. Yao +19 more
TL;DR: This document, developed by experts in laboratory and adult and pediatric clinical medicine, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions.
References
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Journal ArticleDOI
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TL;DR: Moher et al. as mentioned in this paper introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses, which is used in this paper.
Journal Article
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Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States
William W. Thompson,David K. Shay,Eric Weintraub,Lynnette Brammer,Nancy Cox,Larry J. Anderson,Keiji Fukuda +6 more
TL;DR: Mortality associated with both influenza and RSV circulation disproportionately affects elderly persons, and influenza deaths have increased substantially in the last 2 decades, in part because of aging of the population, highlighting the need for better prevention measures, including more effective vaccines and vaccination programs for elderly persons.
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The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews
TL;DR: In this article, an evidence-based quality assessment tool called QUADAS was proposed to assess the quality of primary studies of diagnostic accuracy, based on the results of three previously conducted reviews of the diagnostic literature.
Journal ArticleDOI
Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews.
Johannes B. Reitsma,Afina S. Glas,Anne W S Rutjes,Rob J. P. M. Scholten,Patrick M.M. Bossuyt,Aeilko H. Zwinderman +5 more
TL;DR: The bivariate model can be seen as an improvement and extension of the traditional sROC approach by reanalyzing the data of a published meta-analysis of diagnostic studies reporting pairs of sensitivity and specificity.