Sensitivity of influenza rapid diagnostic tests to H5N1 and 2009 pandemic H1N1 viruses.
Yuko Sakai-Tagawa,Makoto Ozawa,Makoto Ozawa,Daisuke Tamura,Mai thi Quynh Le,Chairul A. Nidom,Norio Sugaya,Yoshihiro Kawaoka +7 more
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TLDR
The results indicate that the detection sensitivity to swine origin H1N1 viruses varies widely among IRDTs, with some tests lacking sufficient sensitivity to detect the early stages of infection when the virus load is low.Abstract:
Simple and rapid diagnosis of influenza is useful for making treatment decisions in the clinical setting. Although many influenza rapid diagnostic tests (IRDTs) are available for the detection of seasonal influenza virus infections, their sensitivity for other viruses, such as H5N1 viruses and the recently emerged swine origin pandemic (H1N1) 2009 virus, remains largely unknown. Here, we examined the sensitivity of 20 IRDTs to various influenza virus strains, including H5N1 and 2009 pandemic H1N1 viruses. Our results indicate that the detection sensitivity to swine origin H1N1 viruses varies widely among IRDTs, with some tests lacking sufficient sensitivity to detect the early stages of infection when the virus load is low.read more
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Rapid diagnostic tests for identifying avian influenza A(H7N9) virus in clinical samples.
Yu Chen,Dayan Wang,Shufa Zheng,Yuelong Shu,Wenxiang Chen,Dawei Cui,Jinming Li,Hongjie Yu,Yu Wang,Lanjuan Li,Hong Shang +10 more
TL;DR: To determine sensitivity of rapid diagnostic tests for detecting influenza A(H7N9) virus, this work compared rapid tests with PCR results and tested different types of clinical samples.
Journal ArticleDOI
Xpert Flu for point-of-care diagnosis of human influenza in industrialized countries.
Nicolas Salez,Antoine Nougairède,Laetitia Ninove,Christine Zandotti,Xavier de Lamballerie,Rémi N. Charrel +5 more
TL;DR: Current knowledge of the Xpert Flu test is reviewed, its potential value as a point-of-care test is discussed, and the potential leads for future development are outlined.
Journal ArticleDOI
Evaluation of twenty‐two rapid antigen detection tests in the diagnosis of Equine Influenza caused by viruses of H3N8 subtype
Takashi Yamanaka,Manabu Nemoto,Hiroshi Bannai,Koji Tsujimura,Takashi Kondo,Tomio Matsumura,Sarah Gildea,Ann Cullinane +7 more
TL;DR: A number of rapid antigen detection tests for diagnosing human influenza are available, but their ability to diagnose EI has not been systematically evaluated.
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Pathology Consultation on Influenza Diagnostics
TL;DR: Diagnostic assays for influenza can vary greatly with regards to analytical performance characteristics, complexity, turnaround time and cost, which can have important patient care and infection prevention implications.
Journal ArticleDOI
The value of radiographic findings for the progression of pandemic 2009 influenza A/H1N1 virus infection
Takanori Funaki,Kensuke Shoji,Nobuyuki Yotani,Tomohiro Katsuta,Osamu Miyazaki,Shunsuke Nosaka,Hidekazu Masaki,Akihiko Saitoh +7 more
TL;DR: Consolidation on initial chest radiographs was the most significant factor to predict clinical course of hospitalized children with the 2009 A/H1N1 infection.
References
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Ron A. M. Fouchier,Peter M. Schneeberger,Frans W. Rozendaal,Jan M. Broekman,Stiena A. G. Kemink,Vincent J. Munster,Thijs Kuiken,Guus F. Rimmelzwaan,Martin Schutten,Gerard J. J. van Doornum,Guus Koch,A Bosman,Marion Koopmans,Albert D. M. E. Osterhaus +13 more
TL;DR: Because H7N7 viruses have caused disease in mammals, including horses, seals, and humans, on several occasions in the past, they may be unusual in their zoonotic potential and, thus, form a pandemic threat to humans.
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Neuraminidase Inhibitors for Influenza
TL;DR: The potential for the development of resistance especially limits the use of the adamantanes for the treatment of influenza, although the drugs still have a place in planning for prophylaxis during an epidemic.
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Janice K. Louie,Meileen Acosta,Kathleen Winter,Cynthia Jean,Shilpa Gavali,Robert Schechter,Duc J. Vugia,Kathleen Harriman,Bela T. Matyas,Carol A. Glaser,Michael Samuel,Jon Rosenberg,John Talarico,Douglas L. Hatch +13 more
TL;DR: In the first 16 weeks of the current pandemic, the median age of hospitalized infected cases was younger than is common with seasonal influenza, and most cases had established risk factors for complications of seasonal influenza.
Journal ArticleDOI
Human infection with influenza H9N2
Malik Peiris,Kwok-Yung Yuen,C. W. Leung,Kwok-Hung Chan,P. L. S. Ip,Raymond Lai,W. K. Orr,Kennedy F. Shortridge +7 more
TL;DR: It is shown that serum samples from blood donors in Hong Kong had neutralising antibody suggestive of prior infection with influenza H9N2.