Journal ArticleDOI
Sequence diversity and evolution of antimicrobial peptides in invertebrates
TLDR
The sequence diversity of invertebrate AMPs (defensins, cecropins, crustins and anti-lipopolysaccharide factors) are presented to provide a better understanding of the evolution pattern of these peptides that play a major role in host defense mechanisms.Abstract:
Antimicrobial peptides (AMPs) are evolutionarily ancient molecules that act as the key components in the invertebrate innate immunity against invading pathogens. Several AMPs have been identified and characterized in invertebrates, and found to display considerable diversity in their amino acid sequence, structure and biological activity. AMP genes appear to have rapidly evolved, which might have arisen from the co-evolutionary arms race between host and pathogens, and enabled organisms to survive in different microbial environments. Here, the sequence diversity of invertebrate AMPs (defensins, cecropins, crustins and anti-lipopolysaccharide factors) are presented to provide a better understanding of the evolution pattern of these peptides that play a major role in host defense mechanisms.read more
Citations
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Journal ArticleDOI
Shrimp humoral responses against pathogens: antimicrobial peptides and melanization.
Anchalee Tassanakajon,Vichien Rimphanitchayakit,Suwattana Visetnan,Piti Amparyup,Kunlaya Somboonwiwat,Walaiporn Charoensapsri,Sureerat Tang +6 more
TL;DR: Interestingly, the pattern recognition protein (PRP) crosstalk is evidenced between the proPO activating cascade and the AMP synthesis pathways in shrimp, which enables the innate immune system to build up efficient immune responses.
Journal ArticleDOI
Convergent evolution of defensin sequence, structure and function
TL;DR: The defensin superfamilies represent a case where the ensuing convergent evolution of sequence, structure and function has been particularly extreme and the extent, causes and significance of these convergent features are discussed.
Journal ArticleDOI
The defensins consist of two independent, convergent protein superfamilies
TL;DR: Evidence is presented that the defensins have not all evolved from a single ancestor, and instead, they consist of two analogous superfamilies, and extensive convergent evolution is the source of their similarities.
Journal ArticleDOI
Antimicrobial peptides in marine invertebrate health and disease.
Delphine Destoumieux-Garzón,Rafael Diego Rosa,Paulina Schmitt,Cairé Barreto,Jeremie Vidal-Dupiol,Guillaume Mitta,Yannick Gueguen,Evelyne Bachère +7 more
TL;DR: The role of the main pathogens and their interaction with host immunity, with a specific focus on antimicrobial peptides (AMPs) and pathogen resistance against AMPs are summarized.
Journal ArticleDOI
A future vision for disease control in shrimp aquaculture
TL;DR: Promising results have been obtained at the laboratory level for possible applications involving the use of immunostimulants for “immune priming” or “trained immunity” of RNA interference and of endogenous viral elements in shrimp–pathogen interactions.
References
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Antimicrobial peptides of multicellular organisms
TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TL;DR: In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.
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Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.
TL;DR: The role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections.
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Mechanisms of Antimicrobial Peptide Action and Resistance
TL;DR: The intention of this review is to illustrate the contemporary structural and functional themes among mechanisms of antimicrobial peptide action and resistance.
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The role of cationic antimicrobial peptides in innate host defences.
TL;DR: Cationic antimicrobial peptides are found in all living species and can have broad-spectrum antibacterial, antifungal, antiviral, antiprotozoan and antisepsis properties and interact directly with host cells to modulate the inflammatory process and innate defences.