Journal ArticleDOI
Sequence of mouse glucose-6-phosphate dehydrogenase cDNA.
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TLDR
A full-length mouse glucose-6-phosphate dehydrogenase (G6PD) cDNA has been isolated and sequenced, and the evolutionary conservation of many portions of the sequence has been verified by comparison with that of human and other sources.Abstract:
A full-length mouse glucose-6-phosphate dehydrogenase (G6PD) cDNA has been isolated and sequenced, and the evolutionary conservation of many portions of the sequence has been verified by comparison with that of human and other sources.read more
Citations
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Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver
TL;DR: It is concluded that expression of nuclear SREBPs is capable of activating the entire coordinated program of unsaturated fatty acid biosynthesis in mouse liver.
Journal ArticleDOI
An embryoprotective role for glucose-6-phosphate dehydrogenase in developmental oxidative stress and chemical teratogenesis
TL;DR: First evidence is shown that G6PD is a developmentally critical cytoprotective enzyme for both endogenous and xenobiotic‐initiated embryopathic oxidative stress and DNA damage, which may have a broader biological relevance as important determinants of infertility, in utero and postnatal death, and teratogenesis.
Journal ArticleDOI
Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress
Stefania Filosa,Annalisa Fico,Francesca Paglialunga,Marco Balestrieri,Almudena Crooke,Pasquale Verde,Paolo Abrescia,José M. Bautista,Giuseppe Martini +8 more
TL;DR: It is found that other reactions provide the cell with a large fraction of NADPH under non-stress conditions, whereas G6PD is the only NADPH-producing enzyme activated in response to oxidative stress, which can act as a guardian of the cell redox potential.
Journal ArticleDOI
Divergence of Spatial Gene Expression Profiles Following Species-Specific Gene Duplications in Human and Mouse
TL;DR: It is concluded that gene duplication is a major driving force behind the emergence of divergent gene expression patterns and that expression in a particular tissue may be gained or lost repeatedly during the evolution of even small gene families.
Journal ArticleDOI
Comparative Approach of the de novo Fatty Acid Synthesis (Lipogenesis) between Ruminant and Non Ruminant Mammalian Species: From Biochemical Level to the Main Regulatory Lipogenic Genes
TL;DR: The main scope of this review is to point out the major differences between ruminant and non ruminants species, that are observed in key regulatory genes involved in lipogenesis.
References
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Journal ArticleDOI
A new method for predicting signal sequence cleavage sites.
TL;DR: A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described.
Journal ArticleDOI
A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: Application to sequencing the corn mitochondrial 18 S rDNA
TL;DR: A simple new procedure was described for producing a sequential series of overlapping clones for use in DNA sequencing by using single-stranded M13 DNA and complementary DNA oligomers to form specific cleavage and ligation substrates.
Book ChapterDOI
Progressive Alignment and Phylogenetic Tree Construction of Protein Sequences
Da-Fei Feng,Russell F. Doolittle +1 more
TL;DR: The preliminary set of pair wise measurements reveals any sub clusters that may exist in the set, which can be treated as units during the alignment process, ensuring that the relative positions of the residues within the cluster will not be altered.
Journal ArticleDOI
Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5' non-coding region.
M.G. Persico,G. Viglietto,G. Martini,Daniela Toniolo,Giacomo Paonessa,C Moscatelli,R. Dono,Tom Vulliamy,Lucio Luzzatto,Michele D'Urso +9 more
TL;DR: The isolation of cDNA clones from HeLa cells, SV40-transformed human fibroblasts, human placenta and human teratocarcinoma cell lines have enabled us to sequence the entire coding region of Gd, providing the entire amino acid sequence of human G6PD for the first time.
Journal ArticleDOI
Isolation and characterization of the ZWF1 gene of Saccharomyces cerevisiae, encoding glucose-6-phosphate dehydrogenase
Ichiro Nogae,Mark Johnston +1 more
TL;DR: The predicted amino acid sequence of yeast G6PD is highly similar to the sequence of the Drosophila, human, and rat enzymes, except near its N terminus, where the yeast and Dosophila sequences diverge from that of human and rat.