Journal ArticleDOI
Sequential Histologic Alterations of Mouse Gastric Mucosa Following Long-Term Simulation of Betel Addiction
TLDR
The Histopathological Effect Of Chewing Of Betel Quid Without Tobacco Was Studied By Simulating 14 Different Chewing Habits Using The Mouse Glandular Stomach Mucosa As A Model Mammalian System to Find Out Whether These Changes Were Erosions and Regenerative Hyperplasia Of The Pyloric Glands.Abstract:
The Histopathological Effect Of Chewing Of Betel Quid Without Tobacco Was Studied By Simulating 14 Different Chewing Habits Using The Mouse Glandular Stomach Mucosa As A Model Mammalian System. Chronic Oral Administration For 8 To 10 Months Resulted In Marked Architectural Atypia In Animals Receiving Extracts Of Areca Catechu L. Red Nut, With Piper Betle L. Varieties and A Combination Of Nut, Leaf and Lime. The Initial Histologic Changes Were Erosions and Regenerative Hyperplasia Of The Pyloric Glands. After Atrophy and Erosion Of The Mucosa, Regenerative Glandular Hyperplasia Developed In Animals Receiving Lime Suspension While Marked Adenomatous Hyperplasia Exhibiting Excessive Glandular Proliferation, Often With Peripheral Growth Into The Stomach Cavity, With Few Cellular Atypism Developed In Animals Receiving Combinations Of P. Betle Var. Bangla, A. Catechu and Low Concentration Of Lime (B Bn Lmn) and A. Catechu With Low Concentration Of Lime (Cbn Lmn). High Dose Of Lime Together With P. Betle...read more
Citations
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Book ChapterDOI
Widespread tannin intake via stimulants and masticatories, especially guarana, kola nut, betel vine, and accessories.
TL;DR: Research and popular education on the deleterious effects of excessive tannin intake could do much to reduce the heavy burden of early mortality and health care, especially in developing countries.
Journal ArticleDOI
Inhibition of clastogenic effects of nicotine by chlorophyllin in mice bone marrow cells in vivo
TL;DR: The use of green plant parts in modifying the genotoxicity of different agents may be related to the protective action of chlorophyllin, which was tested in vivo on mice bone marrow cells.
Journal ArticleDOI
Betel Cytotoxicity: Further Evidence from Mouse Bone Marrow Cells
TL;DR: Tobacco, in any combination of chewing mixture, induced time-dependent clastogenicity and direct damage to chromosomes was observed in the early stage, and lethal effects were observed inThe latter stages of the study.
References
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Journal ArticleDOI
A study of betel quid carcinogenesis. 1. On the in vitro N-nitrosation of arecoline
TL;DR: The hypothesis is that during chewing, arecoline, the major alkaloid of the betel nut, gives rise to carcinogenic N-nitrosamines, which are likely to favor the formation of these three nitrosamines in betel quid chewers.
Book ChapterDOI
Histological Types of Gastric Cancer and its Relationship with Intestinal Metaplasia
Nubia Muñoz,Ivan Matko +1 more
TL;DR: In an attempt to determine if a particular histological type of gastric carcinoma is responsible for these striking features, a modification of the histological classification proposed by LAUREN has been used to classify gastric cancer cases from different geographic areas.
Journal ArticleDOI
Intestinal metaplasia and adenocarcinoma induced in the stomach of rats by N-propyl-N'-nitro-N-nitrosoguanidine.
TL;DR: Intestinal metaplasia was induced in the glandular stomachs of 25%, 75%, and 83% of the rats treated with PNNG for 4, 8, and 12 months, respectively, and Metaplastic glands were found in the pyloric region, especially near the pyleoric ring.
Journal ArticleDOI
Detection of N-nitrosamines in the saliva of habitual chewers of tobacco.
TL;DR: The saliva of habitual chewers of tobacco and of non- chewers was examined using high-performance liquid chromatography and gas-liquid chromatography-thermal energy analysis to detect N-nitroso compounds.
Journal ArticleDOI
Sequential Histologic Changes During Gastric Carcinogenesis Induced by N-Methyl-N′-nitro-N-nitrosoguanidine in Susceptible ACI and Resistant BUF Rats
TL;DR: The results suggested that the responses of the gastric mucosa to MNNG in ACI and BUF rats were qualitatively different.