Journal ArticleDOI
Gastroprotective effects of Dicranopteris linearis leaf extract against ethanol-induced gastric mucosal injury in rats
Jamal Hussaini,Nurul Asyikin Othman,Mahmood Ameen Abdulla,Nazia Abdul Majid,Halabi Mohd Faroq,Salmah Ismail +5 more
TLDR
DLELE was able to decrease the acidity and increase the mucosal defense in the gastric area, thereby justifying its use as an antiulcerogenic agent.Abstract:
Dicranopteris linearis is a medicinal plant commonly used traditionaly in the treatment of many aliments. This study was performed to evaluate the gastroprotective effect of ethanolic extracts of D. linearis leaf extract (DLELE) against ethanol-induced gastric mucosal injury in experimental rats. The rats were divided into four groups respectively pre-treated orally with carboxymethyl cellulose (CMC) solution (ulcer control groups), omeprazole 20 mg/kg (reference group), 250 and 500 mg/kg of DLELE (experimental groups) one hour before oral administration of absolute ethanol to generate gastric mucosal damage. After an additional hour, the rats were sacrificed and the ulcer areas of the gastric walls were determined. The ulcer control group exhibited severe mucosal injury, whereas groups pre-treated with DLELE exhibited significant protection of gastric mucosa. These findings were also confirmed by histology of gastric wall. Significant increases in gastric mucus production and decrease in acidity of gastric content were observed in treated groups with DLELE compare to ulcer control group. In conclusion, treatment with DLELE prior to absolute alcohol has significantly protect gastric mucosa as ascertained grossly by significant reduction of ulcer area, increases in gastric mucus production and decrease the acidity of gastric content and histology by comparatively decreases in gastric mucosal injury, reduction or absence of edema and leucocytes infiltration of submucosal layer compared to ulcer control group. DLELE was able to decrease the acidity and increase the mucosal defense in the gastric area, thereby justifying its use as an antiulcerogenic agent.
Key words: Dicranopteris linearis, cytoprotection, gastric ulcer, mucus, histology.read more
Citations
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Fern-synthesized silver nanocrystals: Towards a new class of mosquito oviposition deterrents?
Rajapandian Rajaganesh,Kadarkarai Murugan,Chellasamy Panneerselvam,Sudalaimani Jayashanthini,Al Thbiani Aziz,Mathath Roni,Udaiyan Suresh,Subrata Trivedi,Hasibur Rehman,Akon Higuchi,Marcello Nicoletti,Giovanni Benelli +11 more
TL;DR: A novel method of fern-mediated biosynthesis of silver nanoparticles (AgNP) using Dicranopteris linearis, acting as a reducing and capping agent, could be useful candidates to develop nano-formulated oviposition deterrents effective against dengue vectors.
Journal ArticleDOI
Effect of methanol extract of Dicranopteris linearis against carbon tetrachloride- induced acute liver injury in rats
Farah Hidayah Kamisan,Farhana Yahya,Siti Syariah Mamat,Mohamad Fauzi Fahmi Kamarolzaman,Norhafizah Mohtarrudin,Teh Lay Kek,Mohd Zaki Salleh,Mohd Khairi Hussain,Zainul Amiruddin Zakaria +8 more
TL;DR: The MEDL showed higher DPPH- and superoxide anion-radical scavenging activity as well as high TPC and ORAC values indicating high antioxidant activity, which demands further investigation.
Journal ArticleDOI
Phytochemical analysis, in vitro antioxidant potential and gas chromatography-mass spectrometry studies of dicranopteris linearis
Kalpana Devi Rajesh,Subramani Vasantha,Annamalai Panneerselvam,Nakulan Valsala Rajesh,N. Jeyathilakan +4 more
TL;DR: In this article, qualitative and quantitative phytochemicals, evaluate in vitro antioxidant properties and determine the bioactive compounds in extracts of Dicranopteris linearis (Burm.f.) underw. collected from Western Ghats of Kanyakumari district.
Journal ArticleDOI
Gastroprotective Effect and Safety Assessment of Zanthoxylum Zanthoxyloides (Lam) Waterm Root Bark Extract
Alex Boye,George Asumeng Koffuor,Johnson Nyarko Boampong,Patrick Amoateng,Elvis Ofori Ameyaw,Ernest Owusu Ansah,Gabriel Manu Addai,Cecilia Konama Adjei,Justice Kwaku Addo,Dennis Korbla Amego Penu +9 more
TL;DR: The ethanolic root bark extract of Zanthoxylum zanthoxyloides has gastroprotective effect in Sprague-Dawley rats working possibly via antimuscarinic or antihistaminic mechanism, however it has a potential of causing cholestasis hence liver function should be monitored.
References
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