Journal ArticleDOI
Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder.
Swen Hesse,Ulrich Müller,Ulrich Müller,Thomas Lincke,Henryk Barthel,Thomas Villmann,Matthias C. Angermeyer,Osama Sabri,Katarina Stengler-Wenzke +8 more
TLDR
Severity of OCD symptoms showed a significant negative correlation with thalamic/hypothalamic SERT availability, and data provide evidence for imbalanced monoaminergic neurotransmitter modulation in OCD.Abstract:
In obsessive-compulsive disorder (OCD), the success of pharmacological treatment with serotonin re-uptake inhibitors and atypical antipsychotic drugs suggests that both the central serotonergic and dopaminergic systems are involved in the pathophysiology of the disorder. We applied [123I]-2beta-carbomethoxy-3beta-(4-idiophenyl)tropane (beta-CIT) and a brain-dedicated high-resolution single photon emission computed tomography (SPECT) system to quantify dopamine transporter (DAT) and serotonin transporter (SERT) availability. By comparing 15 drug-naive patients with OCD and 10 controls, we found a significantly reduced availability (corrected for age) of striatal DAT and of thalamic/hypothalamic, midbrain and brainstem SERT in OCD patients. Severity of OCD symptoms showed a significant negative correlation with thalamic/hypothalamic SERT availability, corrected for age and duration of symptoms. Our data provide evidence for imbalanced monoaminergic neurotransmitter modulation in OCD. Further studies with more selective DAT and SERT radiotracers are needed.read more
Citations
More filters
Journal ArticleDOI
Neurobiological Circuits Regulating Attention, Cognitive Control, Motivation, and Emotion: Disruptions in Neurodevelopmental Psychiatric Disorders
Amy F.T. Arnsten,Katya Rubia +1 more
TL;DR: The role of prefrontal cortical networks in the behavior and cognitive functions that are compromised in childhood neurodevelopmental disorders and how these map into the neuroimaging evidence of circuit abnormalities in these disorders.
Journal ArticleDOI
Sex differences in striatal dopamine release in healthy adults
Cynthia A. Munro,Mary E. McCaul,Dean F. Wong,Lynn M. Oswald,Yun Zhou,James Robert Brašić,Hiroto Kuwabara,Anil Kumar,Mohab Alexander,Weiguo Ye,Gary S. Wand +10 more
TL;DR: The robust dopamine release in men could account for increased vulnerability to stimulant use disorders and methamphetamine toxicity and may have implications for the interpretation of sex differences in other illnesses involving the striatum.
Journal ArticleDOI
The neurobiology of repetitive behavior: ...and men.
TL;DR: This work synthesizes the 'disorder-driven' literature and suggests a model for classifying repetitive behavior by its neuroanatomical correlates, building on findings from fundamental animal research and translational models.
Journal ArticleDOI
Cortical GABA, Striatal Dopamine and Midbrain Serotonin as the Key Players in Compulsive and Anxiety Disorders - Results from In Vivo Imaging Studies
TL;DR: The results show that DA, 5-HT, and GABA play a major role in all subtypes of anxiety disorders and imply that the regulation state of DA as modulated by GABA and5-HT may be crucial for the development of anxiety- and compulsion-related disorders.
Journal ArticleDOI
Dopaminergic control of cognitive flexibility in humans and animals.
TL;DR: Findings from animal and human studies that have investigated the involvement of striatal DA in cognitive flexibility may provide a better understanding of the role of dopaminergic dysfunction in cognitive inflexibility in psychiatric disorders, such as OCD.
References
More filters
Journal ArticleDOI
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Wayne K. Goodman,Lawrence H. Price,Steven A. Rasmussen,Carolyn M. Mazure,Roberta L. Fleischmann,Candy L. Hill,George R. Heninger,Dennis S. Charney +7 more
TL;DR: In a study involving four raters and 40 patients with obsessive-compulsive disorder at various stages of treatment, interrater reliability for the total Yale-Brown Scale score and each of the 10 individual items was excellent, with high degree of internal consistency among all item scores demonstrated with Cronbach's alpha coefficient.
Journal ArticleDOI
The Yale-Brown Obsessive Compulsive Scale: II. Validity
Wayne K. Goodman,Lawrence H. Price,Steven A. Rasmussen,Carolyn M. Mazure,Pedro L. Delgado,George R. Heninger,Dennis S. Charney +6 more
TL;DR: Results from a previously reported placebo-controlled trial of fluvoxamine in 42 patients with obsessive-compulsive disorder showed that the Yale- Brown Scale was sensitive to drug-induced changes and that reductions in Yale-Brown Scale scores specifically reflected improvement in obsessive- compulsive disorder symptoms.
Journal ArticleDOI
The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency
Suck Won Kim,Maurice W. Dysken,Alfred M. Pheley,Alfred M. Pheley,Kathleen Maxwell Hoover,Kathleen Maxwell Hoover +5 more
TL;DR: Examination of the postreatment factor scores showed that the Y-BOCS resistance items did not assess OCD symptom change as sensitively as the rest of the Y, Brown Obsessive-Compulsive Scale items did.
Journal ArticleDOI
Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder.
Sanjaya Saxena,Scott L. Rauch +1 more
TL;DR: This work has shown that interventions that directly alter the indirect-direct pathway balance within frontal-subcortical circuits will allow for direct testing of the pathophysiologic hypotheses presented here.
Journal ArticleDOI
Tourette's syndrome.
TL;DR: A new perspective is offered on the understanding of the pathogenesis of Tourette's syndrome and on principles for treatment of patients with this disorder.