Silk-based delivery systems of bioactive molecules.
Keiji Numata,David L. Kaplan +1 more
TLDR
The utility of silk-based multi-block copolymer systems and related silk protein drug delivery systems for the delivery of small molecule drugs, proteins and genes is reviewed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2010-12-30 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Drug delivery & Genetic transfer.read more
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Soft robotics: a bioinspired evolution in robotics.
TL;DR: Emerging soft-bodied robotic systems are reviewed to endow robots with new, bioinspired capabilities that permit adaptive, flexible interactions with unpredictable environments and to reduce the mechanical and algorithmic complexity involved in robot design.
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Advanced materials and processing for drug delivery: The past and the future
TL;DR: In this review, this review focuses on the materials innovation and processing of drug delivery systems and how these advances have shaped the past and may influence the future of drug Delivery.
Journal ArticleDOI
Structures, mechanical properties and applications of silk fibroin materials
Leng-Duei Koh,Leng-Duei Koh,Yuan Cheng,Choon-Peng Teng,Choon-Peng Teng,Yin-Win Khin,Xian Jun Loh,Si Yin Tee,Si Yin Tee,Michelle Low,Enyi Ye,Hai-Dong Yu,Yong-Wei Zhang,Ming-Yong Han,Ming-Yong Han +14 more
TL;DR: In this article, a review of the current understandings of the constituents, structures, and mechanical properties of silk fibroin is presented, and the strategies to bring its mechanical performance closer to that of spider dragline silk are discussed.
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Protein-based nanocarriers as promising drug and gene delivery systems
TL;DR: The current review highlights the main advances achieved in utilizing protein nanocarriers as natural vehicles for drug and gene delivery tasks with respect to types, advantages, limitations, formulation aspects as well as the major outcomes of the in vitro and in vivo investigations.
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Designing degradable hydrogels for orthogonal control of cell microenvironments
TL;DR: This review provides insight into emerging degradable and cell-compatible hydrogels for understanding and modulating cell behavior for various bioengineering applications.
References
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Journal ArticleDOI
Silk-based biomaterials
Gregory H. Altman,Frank Diaz,Caroline M. Jakuba,Tara Calabro,Rebecca L. Horan,Jingsong Chen,Helen H. Lu,John C. Richmond,David L. Kaplan +8 more
TL;DR: Studies with well-defined silkworm silk fibers and films suggest that the core silk fibroin fibers exhibit comparable biocompatibility in vitro and in vivo with other commonly used biomaterials such as polylactic acid and collagen.
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Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model
TL;DR: In vivo selection of phage display libraries was used to isolate peptides that home specifically to tumor blood vessels that enhanced the efficacy of the anticancer drug doxorubicin and reduced its toxicity.
PatentDOI
Cell penetrating peptides
TL;DR: In this article, the present invention discloses cell penetrating peptides and conjugates of a cell-penetrating peptide and a cargo molecule, as well as their conjugations.
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Collagen fibril formation
TL;DR: Preliminary evidence from invertebrates is included which suggests that the principles for bipolar fibril assembly were established at least 500 million years ago, and how mature fibrils are assembled from early fibrILS is reviewed.
Journal ArticleDOI
Liquid crystalline spinning of spider silk.
Fritz Vollrath,David P. Knight +1 more
TL;DR: Successful copying of the spider's internal processing and precise control over protein folding, combined with knowledge of the gene sequences of its spinning dopes, could permit industrial production of silk-based fibres with unique properties under benign conditions.