Journal ArticleDOI
Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis
Mei Jing Piao,Kyoung Ah Kang,In Kyung Lee,Hye Sun Kim,Suhkmann Kim,Jeong Yun Choi,Jinhee Choi,Jin Won Hyun +7 more
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TLDR
In this paper, the authors investigated the possible molecular mechanisms underlying the cytotoxic effects of AgNPs and found that AgNs induced reactive oxygen species (ROS) generation and suppression of reduced glutathione (GSH) in human Chang liver cells.About:
This article is published in Toxicology Letters.The article was published on 2011-02-25. It has received 575 citations till now. The article focuses on the topics: Cell damage & Oxidative stress.read more
Citations
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The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.
TL;DR: Findings on the role of surface charge on cytotoxicity in general, action on specific cellular targets, modes of toxic action, cellular uptake, and intracellular localization of NPs are summarized.
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Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal
TL;DR: It can be concluded that the therapeutic window for silver is narrower than often assumed, however, the risks for humans and the environment are probably limited.
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Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches
TL;DR: This review extensively discusses the multifunctional bio-applications of AgNPs; for example, as antibacterial, antifungal, antiviral,Anti-inflammatory, anti-angiogenic, and anti-cancer agents, and the mechanism of the anti- cancer activity of Ag NPs.
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Biological Synthesis of Nanoparticles from Plants and Microorganisms
TL;DR: The potential uses of various biological sources for nanoparticle synthesis and the application of those nanoparticles are explored and the recent milestones achieved are highlighted by controlling critical parameters, including the choice of biological source, incubation period, pH, and temperature.
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Antibacterial activity of silver nanoparticles: A surface science insight
TL;DR: In this paper, the main parameters that will affect the surface state of nanoparticles and their influence on antimicrobial efficacy are reviewed and an analysis of several works on Ag NPs activity, observed through the scope of an oxidative Ag+ release.
References
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Mitochondria and apoptosis
Douglas R. Green,John C. Reed +1 more
TL;DR: A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins.
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Toxic Potential of Materials at the Nanolevel
TL;DR: The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.
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Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Peng Li,Deepak Nijhawan,Imawati Budihardjo,Srinivasa M. Srinivasula,Manzoor Ahmad,Emad S. Alnemri,Xiaodong Wang +6 more
TL;DR: Mutation of the active site of caspase-9 attenuated the activation of cazase-3 and cellular apoptotic response in vivo, indicating that casp enzyme-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP.
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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin,M. Flint Beal +1 more
TL;DR: Treatments targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise in ageing-related neurodegenerative diseases.
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Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.