Open AccessDissertation
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
Reads0
Chats0
About:
The article was published on 2003-01-01 and is currently open access. It has received 135 citations till now.read more
Citations
More filters
Journal ArticleDOI
Toll-like receptors in innate immunity.
Kiyoshi Takeda,Shizuo Akira +1 more
TL;DR: Toll-like receptors-mediated activation of innate immunity controls not only host defense against pathogens but also immune disorders, and the involvement of TLR-mediated pathways in autoimmune and inflammatory diseases has been proposed.
Journal ArticleDOI
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
TL;DR: The function of the fifth adaptor, SARM, has been revealed, which negatively regulates TRIF, and it is shown that it acts as a bridging adaptor in the initiation of TLR signalling.
Journal ArticleDOI
SOCS proteins, cytokine signalling and immune regulation.
TL;DR: This review brings together data from recent studies on SOCS proteins and their role in immunity, and proposes a cohesive model of how cytokine signalling regulates immune-cell function.
Journal ArticleDOI
microRNA Regulation of Inflammatory Responses
TL;DR: Recent advances in the understanding of miRNAs and their connection to inflammatory responses are discussed, and the link between perturbations in miRNA levels and the onset of human inflammatory diseases is considered.
Journal ArticleDOI
PI3K and negative regulation of TLR signaling.
Taro Fukao,Shigeo Koyasu +1 more
TL;DR: PI3K, IRAK-M and SOCS-1 have unique roles in the gate-keeping system, preventing excessive innate immune responses.
References
More filters
Journal ArticleDOI
Toll-like receptors in innate immunity.
Kiyoshi Takeda,Shizuo Akira +1 more
TL;DR: Toll-like receptors-mediated activation of innate immunity controls not only host defense against pathogens but also immune disorders, and the involvement of TLR-mediated pathways in autoimmune and inflammatory diseases has been proposed.
Journal ArticleDOI
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
TL;DR: The function of the fifth adaptor, SARM, has been revealed, which negatively regulates TRIF, and it is shown that it acts as a bridging adaptor in the initiation of TLR signalling.
Journal ArticleDOI
SOCS proteins, cytokine signalling and immune regulation.
TL;DR: This review brings together data from recent studies on SOCS proteins and their role in immunity, and proposes a cohesive model of how cytokine signalling regulates immune-cell function.
Journal ArticleDOI
New regulators of NF-kappaB in inflammation.
Sankar Ghosh,Matthew S. Hayden +1 more
TL;DR: This Review discusses new insights into the regulation of NF-κB, a key mediator of inducible transcription in the immune system, that have been identified and some of the known components have been assigned new roles.
Journal ArticleDOI
microRNA Regulation of Inflammatory Responses
TL;DR: Recent advances in the understanding of miRNAs and their connection to inflammatory responses are discussed, and the link between perturbations in miRNA levels and the onset of human inflammatory diseases is considered.