Journal ArticleDOI
microRNA Regulation of Inflammatory Responses
TLDR
Recent advances in the understanding of miRNAs and their connection to inflammatory responses are discussed, and the link between perturbations in miRNA levels and the onset of human inflammatory diseases is considered.Abstract:
The mammalian inflammatory response is a rapid and complex physiological reaction to noxious stimuli including microbial pathogens. Although inflammation plays a valuable role in combating infection, its dysregulation often occurs in people and can cause a variety of pathologies, ranging from chronic inflammation, to autoimmunity, to cancer. In recent years, our understanding of both the cellular and molecular networks that regulate inflammation has improved dramatically. Although much of the focus has been on the study of protein regulators of inflammation, recent evidence also points to a critical role for a specific class of noncoding RNAs, called microRNAs (miRNAs), in managing certain features of the inflammatory process. In this review, we discuss recent advances in our understanding of miRNAs and their connection to inflammatory responses. Additionally, we consider the link between perturbations in miRNA levels and the onset of human inflammatory diseases.read more
Citations
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Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders.
TL;DR: The molecular mechanisms of the antagonistic signaling between NF-κB and SIRT1 are examined and how this crosstalk controls inflammatory process and energy metabolism is described to induce the appearance of chronic inflammation in metabolic diseases.
Journal ArticleDOI
MicroRNAs as regulatory elements in immune system logic
Arnav Mehta,David Baltimore +1 more
TL;DR: The mechanisms by which several miRNAs influence immune development and buffer normal haematopoietic output are discussed, first at the level of haematic stem cells, then in innate and adaptive immune cells, and the pathological consequences of dysregulation of these mi RNAs are discussed.
Journal ArticleDOI
Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome.
TL;DR: The key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling are discussed, with emphasis on the negative regulation of the NF-κB pathway and the NLRP3 inflammasome.
Journal ArticleDOI
Macrophage phenotypes in atherosclerosis.
TL;DR: The present review summarizes the current knowledge on macrophage subsets in atherosclerotic plaques and mechanism behind the modulation of the macrophages phenotype.
Journal ArticleDOI
Injectable Graphene Oxide/Hydrogel-Based Angiogenic Gene Delivery System for Vasculogenesis and Cardiac Repair
Arghya Paul,Arghya Paul,Arghya Paul,Anwarul Hasan,Anwarul Hasan,Hamood Al Kindi,Akhilesh K. Gaharwar,Vijayaraghava T.S. Rao,Mehdi Nikkhah,Mehdi Nikkhah,Su Ryon Shin,Su Ryon Shin,Su Ryon Shin,Dorothee Krafft,Dorothee Krafft,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Dominique Shum-Tim,Ali Khademhosseini +18 more
TL;DR: The current findings suggest the feasibility of a combined hydrogel-based gene therapy system for ischemic heart diseases using nonviral hybrid complex of fGO and DNA.
References
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Journal ArticleDOI
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal ArticleDOI
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent advances that have been made by research into the role of TLR biology in host defense and disease are described.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
Journal ArticleDOI
MicroRNA signatures in human cancers
George A. Calin,Carlo M. Croce +1 more
TL;DR: MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment and has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.
Journal Article
MicroRNA signatures in human cancers
George A. Calin,Carlo M. Croce +1 more
TL;DR: The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery as discussed by the authors.